Mimics and cross reactions of relevance to tumour immunotherapy

MUC1 has been used as a target for immunotherapy and with oxidised mannan in mice there is selective delivery into the class I pathway and the induction of a T1 response. We have also been working in pig-to-human transplantation and of particular interest is the description in humans of natural Galα...

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Bibliographic Details
Published in:Vaccine 1999-09, Vol.18 (3), p.268-275
Main Authors: Apostolopoulos, Vasso, Sandrin, Mauro S., McKenzie, Ian F.C.
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Autoimmune Diseases - etiology
Biological and medical sciences
Cross Reactions
Humans
Immunotherapy
mannan
Medical sciences
Mice
Mimics
Molecular Mimicry
MUC-1 antigen
MUC1
Neoplasms, Experimental - therapy
Pharmacology. Drug treatments
Sequence Analysis, Protein
Swine
Transplantation, Heterologous
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Summary:MUC1 has been used as a target for immunotherapy and with oxidised mannan in mice there is selective delivery into the class I pathway and the induction of a T1 response. We have also been working in pig-to-human transplantation and of particular interest is the description in humans of natural Galα(1,3)Gal antibodies (Abs) which react with pig tissues. A peptide mimic (DAHWESWL) to the Galα(1,3)Gal sugar was found in a phage display library and is also mimicked by MUC1 peptides. It was of interest to note that while mice make cytotoxic T cells (CTLs) and little Ab to MUC1, humans make the reverse immune response. It was found that the cross reaction of the natural Galα(1,3)Gal Abs in humans to MUC1 was likely to be responsible for the diversion. Cross reactions are therefore an important problem in tumour immunotherapy, although the problem can be overcome by in vitro immunisations.
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(99)00197-8