Magnetization transfer in MRI: a review

This review describes magnetization transfer (MT) contrast in magnetic resonance imaging. A qualitative description of how MT works is provided along with experimental evidence that leads to a quantitative model for MT in tissues. The implementation of MT saturation in imaging sequences and the inte...

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Bibliographic Details
Published in:NMR in biomedicine 2001-04, Vol.14 (2), p.57-64
Main Authors: Henkelman, R. M., Stanisz, G. J., Graham, S. J.
Format: Article
Language:English
Subjects:
Biophysical Phenomena
Biophysics
Humans
Macromolecular Substances
Magnetic Resonance Angiography
Magnetic Resonance Imaging
Magnetics
magnetization transfer
MRI
Water
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Summary:This review describes magnetization transfer (MT) contrast in magnetic resonance imaging. A qualitative description of how MT works is provided along with experimental evidence that leads to a quantitative model for MT in tissues. The implementation of MT saturation in imaging sequences and the interpretation of the MT‐induced signal change in terms of exchange processes and direct effects are presented. Finally, highlights of clinical uses of MT are outlined and future directions for investigation proposed. Copyright © 2001 John Wiley & Sons, Ltd. Abbreviations used: Beff effective magnetic field CRMG Carr–Purcell–Meiboom–Gill CW continuous wave FAIR flow sensitive alternating inversion recovery Gd‐DTPA gadolinium diethylenetriminepentaacetic acid MRA magnetic resonance angiography MRI magnetic resonance imaging MS multiple sclerosis MT magnetization transfer MTR magnetization transfer ratio RF radio frequency SAR specific absorption rate.
ISSN:0952-3480
1099-1492
DOI:10.1002/nbm.683