Clones of Streptococcus pneumoniae Isolated from Nasopharyngeal Carriage and Invasive Disease in Young Children in Central Tennessee

To determine whether nasopharyngeal carriage isolates of Streptococcus pneumoniae are of the same genetic background as isolates that caused invasive disease in one community, IS1167 and boxA genotypes were obtained for 182 pneumococcal isolates from children living in central Tennessee. The isolate...

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Bibliographic Details
Published in:The Journal of infectious diseases 2001-05, Vol.183 (10), p.1501-1507
Main Authors: Robinson, D. Ashley, Edwards, Kathryn M., Waites, Ken B., Briles, David E., Crain, Marilyn J., Hollingshead, Susan K.
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Atherosclerosis (general aspects, experimental research)
Bacterial Capsules - immunology
Biological and medical sciences
Blood and lymphatic vessels
boxA gene
Cardiology. Vascular system
Carrier State
Child, Preschool
Clone Cells - immunology
Diversity indices
DNA Transposable Elements
Epidemiology
Female
Genetic diseases
Genetic Markers
Genetic Variation
Genotype
Genotypes
Humans
Infant
Major Articles
Male
Medical genetics
Medical sciences
Nasopharyngeal diseases
Nasopharynx - microbiology
Penicillin
Pharmacology. Drug treatments
Phylogeny
Plant diseases
Pneumococcal Infections - microbiology
Population genetics
Streptococcus pneumoniae
Streptococcus pneumoniae - genetics
Streptococcus pneumoniae - immunology
Streptococcus pneumoniae - isolation & purification
Tennessee
USA, Tennessee
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Summary:To determine whether nasopharyngeal carriage isolates of Streptococcus pneumoniae are of the same genetic background as isolates that caused invasive disease in one community, IS1167 and boxA genotypes were obtained for 182 pneumococcal isolates from children living in central Tennessee. The isolates represented 70 combined IS1167-boxA genotypes. The genotypic diversity of the invasive isolates was significantly less than that of the total population (P=.003). Most of the carriage isolates belonged to genotypes unique to carriage, whereas most of the invasive isolates belonged to genotypes common to carriage and disease (P=.02). Monte Carlo simulations showed a greater number of genotypes unique to carriage than can be explained by chance (P
ISSN:0022-1899
1537-6613
DOI:10.1086/320194