Four new inverted terminal repeat sequences from bovine adenoviruses reveal striking differences in the length and content of the ITRs

The inverted terminal repeat (ITR) of the genome of four bovine adenovirus (BAdV) types have been sequenced, analysed and compared to the ITRs of other adenoviruses. The length of ITRs of the examined BAdVs ranged between 59 and 368 base pairs, thus the presently known longest adenovirus ITR sequenc...

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Bibliographic Details
Published in:Virus genes 2001-03, Vol.22 (2), p.175-179
Main Authors: Dán, A, Elo, P, Harrach, B, Zádori, Z, Benko, M
Format: Article
Language:English
Subjects:
Adenovirus E2 Proteins - genetics
Animals
Base Sequence
Bovine adenovirus
Cattle
DNA, Viral
Genes, Viral
Humans
Mastadenovirus - genetics
Molecular Sequence Data
NFI protein
Sequence Homology, Nucleic Acid
Terminal Repeat Sequences
Viral Core Proteins - genetics
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Summary:The inverted terminal repeat (ITR) of the genome of four bovine adenovirus (BAdV) types have been sequenced, analysed and compared to the ITRs of other adenoviruses. The length of ITRs of the examined BAdVs ranged between 59 and 368 base pairs, thus the presently known longest adenovirus ITR sequence is from BAdV-10. The conserved motifs and characteristic sequence elements of the ITRs providing different binding sites for replicative proteins of viral and cellular origin seemed to be distributed according to the proposed genus classification of BAdVs. The ITRs of BAdV-10 share similarity with the members of the genus Mastadenovirus, while the ITRs of the other three sequenced serotypes (BAdV-4, 5 and strain Rus) which are candidate members of the genus Atadenovirus are very short and contain NFI and Sp1 binding sites only. The analysis of the new ITRs implied that the nucleotide sequence of the so-called core origin is highly preserved within the mastadenovirus genus only.
ISSN:0920-8569
1572-994X
DOI:10.1023/A:1008125324346