Determination of gas phase peroxyacetic acid using pre-column derivatization with organic sulfide reagents and liquid chromatography

The first selective HPLC methods for the determination of peroxyacetic acid (PAA) in gas phase samples have been developed. PAA reacts with 2-([3-{2-[4-amino-2-(methylsulfanyl)phenyl]-1-diazenyl}phenyl]sulfonyl)-1-ethanol (ADS) to form the corresponding sulfoxide. Sampling may be performed in imping...

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Bibliographic Details
Published in:Journal of Chromatography A 1999-09, Vol.855 (2), p.551-561
Main Authors: Effkemann, Stefan, Brødsgaard, Søren, Mortensen, Peter, Linde, Svend-Aage, Karst, Uwe
Format: Article
Language:English
Subjects:
Amino(methylsulfanyl)phenyldiazenylphenylsulfonylethanol
Analytical chemistry
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Chemistry
Chromatographic methods and physical methods associated with chromatography
Chromatography, High Pressure Liquid - methods
Exact sciences and technology
Gas, fumes
Gases - chemistry
Indicators and Reagents - chemistry
Medical sciences
Methyltolyl sulfide
Other chromatographic methods
Peracetic Acid - analysis
Peroxides
Peroxyacetic acid
Spectrophotometry, Ultraviolet
Sulfides - chemistry
Toxicology
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Summary:The first selective HPLC methods for the determination of peroxyacetic acid (PAA) in gas phase samples have been developed. PAA reacts with 2-([3-{2-[4-amino-2-(methylsulfanyl)phenyl]-1-diazenyl}phenyl]sulfonyl)-1-ethanol (ADS) to form the corresponding sulfoxide. Sampling may be performed in impingers using aqueous solutions of the reagent or by test tubes with the reagent coated on a solid sorbent. Sulfide and sulfoxide are separated by means of HPLC and detected at a wavelength of 410 nm. The method is highly selective for PAA in the presence of hydrogen peroxide when sampling in impingers. A 10 000-fold excess of hydrogen peroxide leads to the same peak area compared to PAA. Limit of detection is 10 −8 mol PAA, thus corresponding to PAA concentration of 46 ppb when using a sampling time of 10 min with a flow-rate at 500 ml/min. Another sulfide reagent, methyl- p-tolyl sulfide (MTS) has been used in a similar way with impinger sampling. Major advantages of ADS towards MTS are improved UV–Vis spectroscopic properties and reduced volatility.
ISSN:0021-9673
DOI:10.1016/S0021-9673(99)00734-7