beta(2)-adrenergic receptor overexpression exacerbates development of heart failure after aortic stenosis

Beta-adrenergic signaling is downregulated in the failing heart, and the significance of such change remains unclear. To address the role of beta-adrenergic dysfunction in heart failure (HF), aortic stenosis (AS) was induced in wild-type (WT) and transgenic (TG) mice with cardiac targeted overexpres...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2000-01, Vol.101 (1), p.71-77
Main Authors: Du, X J, Autelitano, D J, Dilley, R J, Wang, B, Dart, A M, Woodcock, E A
Format: Article
Language:English
Subjects:
Animals
Aortic Valve Stenosis - complications
Aortic Valve Stenosis - pathology
Aortic Valve Stenosis - physiopathology
Atrial Natriuretic Factor - genetics
Body Weight
Heart Failure - etiology
Heart Failure - pathology
Heart Failure - physiopathology
Heart Rate
Hypertrophy, Left Ventricular - physiopathology
Mice
Mice, Transgenic
Myocardium - pathology
Organ Size
Pleural Effusion - physiopathology
Receptors, Adrenergic, beta-2 - genetics
Receptors, Adrenergic, beta-2 - physiology
RNA, Messenger - genetics
Systole
Transcription, Genetic
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Summary:Beta-adrenergic signaling is downregulated in the failing heart, and the significance of such change remains unclear. To address the role of beta-adrenergic dysfunction in heart failure (HF), aortic stenosis (AS) was induced in wild-type (WT) and transgenic (TG) mice with cardiac targeted overexpression of beta(2)-adrenergic receptors (ARs), and animals were studied 9 weeks later. The extents of increase in systolic arterial pressure (P
ISSN:0009-7322
DOI:10.1161/01.CIR.101.1.71