Association of Circulating Cellular Adhesion Molecules with Menopausal Status and Hormone Replacement Therapy: Time-Dependent Change in Transdermal, but not Oral Estrogen Users

The incidence of coronary heart disease is lower in premenopausal than in postmenopausal women, and estrogen use may be cardioprotective among postmenopausal women. Cellular adhesion molecules (CAM) are involved in the early stage of atherosclerosis, and short-term administration of oral estrogen de...

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Bibliographic Details
Published in:Thrombosis research 2001-01, Vol.101 (2), p.35-43
Main Authors: Oger, Emmanuel, Alhenc-Gelas, Martine, Plu-Bureau, Geneviève, Mennen, Louise, Cambillau, Michèle, Guize, Louis, Pujol, Yamilée, Scarabin, Pierre-Yves
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Administration, Oral
Analysis of Variance
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Case-Control Studies
Cell adhesion molecule
Cell Adhesion Molecules - blood
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
E-Selectin - blood
Estrogens - administration & dosage
Estrogens - pharmacology
Female
Hormone replacement therapy
Hormone Replacement Therapy - methods
Humans
Intercellular Adhesion Molecule-1 - blood
Medical sciences
Menopause
Menopause - blood
Middle Aged
P-Selectin - blood
Time Factors
Vascular Cell Adhesion Molecule-1 - blood
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Summary:The incidence of coronary heart disease is lower in premenopausal than in postmenopausal women, and estrogen use may be cardioprotective among postmenopausal women. Cellular adhesion molecules (CAM) are involved in the early stage of atherosclerosis, and short-term administration of oral estrogen decreased plasma concentrations of their soluble forms in postmenopausal women. However, data evaluating transdermal estrogen are sparse and long-term effect of hormone replacement therapy (HRT) on CAM is unknown. Therefore, we have investigated the association of circulating CAM (cCAM) with menopausal status and long-term HRT. Plasma levels of intercellular adhesion molecule-1 (cICAM-1), vascular cell adhesion molecule-1 (cVCAM-1), P-selectin, E-selectin, C-reactive protein (CRP), and fibrinogen were measured in 74 premenopausal women, 60 postmenopausal women not using HRT, 30 postmenopausal women using opposed oral estrogen therapy, and 30 postmenopausal women using opposed transdermal estrogen therapy. All women were apparently healthy and aged between 45 and 54 years. Duration of HRT ranged from 3 to 96 months. Postmenopausal women not receiving HRT had 24% higher mean levels of cICAM-1 than premenopausal women (318 vs. 255 ng/ml, P
ISSN:0049-3848
1879-2472
DOI:10.1016/S0049-3848(00)00382-0