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Recent advances in xenotransplantation
The major barrier to clinically successful pig-to-human xenotransplantation is antibody- and complement-dependent hyperacute rejection, known to be due to host anti-Galα(1,3)Gal antibodies. Strategies aimed at eliminating hyperacute rejection involve transgenic approaches to eliminate or reduce expr...
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| Published in: | Current Opinion in Immunology 1999-10, Vol.11 (5), p.527-531 |
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| Main Authors: | , |
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| Language: | English |
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| container_end_page | 531 |
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| container_start_page | 527 |
| container_title | Current Opinion in Immunology |
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| creator | Sandrin, Mauro S McKenzie, Ian FC |
| description | The major barrier to clinically successful pig-to-human xenotransplantation is antibody- and complement-dependent hyperacute rejection, known to be due to host anti-Galα(1,3)Gal antibodies. Strategies aimed at eliminating hyperacute rejection involve transgenic approaches to eliminate or reduce expression of Galα(1,3)Gal or to reduce complement activation; some of these are now in clinical trials in primates. Another important role of Galα(1,3)Gal that is becoming more evident is in antibody-dependent and -independent xenograft rejection that is mediated by natural killer cells and monocytes. |
| doi_str_mv | 10.1016/S0952-7915(99)00011-4 |
| format | article |
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| ispartof | Current Opinion in Immunology, 1999-10, Vol.11 (5), p.527-531 |
| issn | 0952-7915 1879-0372 |
| language | eng |
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| source | Elsevier |
| subjects | Animals Animals, Genetically Modified - immunology Antibody Antigen Presentation CD1 Disaccharides - biosynthesis Disaccharides - immunology Endogenous Retroviruses Epitopes Graft Rejection - prevention & control Humans Pig models Swine - genetics Swine - immunology Swine - virology Tolerance Transplantation, Heterologous - immunology Xenotransplantation |
| title | Recent advances in xenotransplantation |
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