Antibodies against pneumococcal polysaccharides after vaccination in HIV-infected individuals: 5-year follow-up of antibody concentrations

We studied the production of IgG antibodies against eight pneumococcal polysaccharide serotypes (PPS) 1, 4, 6B, 9V, 14, 18C, 19F and 23F after vaccination of 50 HIV-infected adults with 23-valent Pneumovax ®23 and the course of the antibodies against four PPS during the following years. Mean antibod...

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Bibliographic Details
Published in:Vaccine 1999-10, Vol.18 (5), p.524-530
Main Authors: Kroon, Frank P, van Dissel, Jaap T, Ravensbergen, Elisabeth, Nibbering, Peter H, van Furth, Ralph
Format: Article
Language:English
Subjects:
Adult
AIDS/HIV
Antibodies, Bacterial - blood
Bacterial Vaccines - immunology
Biological and medical sciences
CD4 + T-lymphocytes
Epidemiology. Vaccinations
Female
Follow-Up Studies
General aspects
HIV Infections - immunology
HIV-infection
human immunodeficiency virus
Humans
Infectious diseases
Male
Medical sciences
Middle Aged
Pneumococcal polysaccharide vaccine
Pneumococcal Vaccines
polysaccharides
Streptococcus pneumoniae
Streptococcus pneumoniae - immunology
T-Lymphocytes - immunology
Time Factors
Vaccination
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Summary:We studied the production of IgG antibodies against eight pneumococcal polysaccharide serotypes (PPS) 1, 4, 6B, 9V, 14, 18C, 19F and 23F after vaccination of 50 HIV-infected adults with 23-valent Pneumovax ®23 and the course of the antibodies against four PPS during the following years. Mean antibody concentrations against PPS 18C, 19F and 23F were sigificantly lower in the patients with CD4 +-lymphocyte counts
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(99)00240-6