Conditioned blood reperfusion during angioplasty (CoBRA) treatment of acute myocardial infarction

Acute myocardial infarct (MI) results in ischemia distal to lesions which puts heart muscle at risk for reperfusion injury (RI). Neutrophils, platelets and complement are putative mediators of RI. Recent advances in filtration technology provide integrated neutrophil and platelet removal together wi...

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Bibliographic Details
Published in:Perfusion 2001-03, Vol.16 (1_suppl), p.39-49
Main Authors: Patel, Mrugesh B, Kilgore, Kenneth S, Ortolano, Girolamo A, Gryboski, Cyndy L, Qureshi, Mansoor A, Marcovitz, Pamela, Naylor, Keith B, Park, James L, Wenz, Barry, Gikakis, Nicolas, Freedman, Robert J, Lucchesi, Benedict R, O’Neill, William W
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Angioplasty
Angioplasty, Balloon, Coronary - methods
Animals
Arteries
Blood flow
Blood plasma
Blood pressure
Cardiac muscle
Complement
Complement Membrane Attack Complex - metabolism
Complement Membrane Attack Complex - pharmacology
Complications
Conditioning
Coronary artery
Coronary vessels
Creatine
Creatine kinase
Electrocardiography
Female
Filtration
Filtration - methods
Health risks
Heart
Hemoperfusion
Humans
In Vitro Techniques
Indication
Integration
Ischemia
Lesions
Leukapheresis
Leukocytes
Leukocytes (neutrophilic)
Lymph
Male
Membrane attack complex
Middle Aged
Myocardial infarction
Myocardial Infarction - blood
Myocardial Infarction - physiopathology
Myocardial Infarction - surgery
Myocardium
Pilot Projects
Plateletpheresis
Platelets
Prospective Studies
Rabbits
Reperfusion
Reperfusion - methods
Reperfusion Injury - etiology
Reperfusion Injury - prevention & control
Stroke Volume
Ventricle
Ventricular Function, Left
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Description
Summary:Acute myocardial infarct (MI) results in ischemia distal to lesions which puts heart muscle at risk for reperfusion injury (RI). Neutrophils, platelets and complement are putative mediators of RI. Recent advances in filtration technology provide integrated neutrophil and platelet removal together with complement-attenuating properties in a single blood-conditioning device. The present study characterizes the properties of a blood-conditioning filter and describes its clinical effect when used in conjunction with active hemoperfusion for acute MI.The filter reduces leukocytes by 99.9998 ± 0.0002% (p
ISSN:0267-6591
1477-111X
DOI:10.1177/026765910101600i106