Recognition by macrophages and liver cells of opsonized phospholipid vesicles and phospholipid headgroups

The interaction of liposomes with blood proteins is believed to play a critical role in the clearance pharmacokinetics and tissue distribution of intravenously injected liposomes. In this article we have focused our discussion on the interaction of liposomes with key blood proteins, which include im...

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Bibliographic Details
Published in:Pharmaceutical research 2001, Vol.18 (1), p.1-8
Main Authors: MOEIN MOGHIMI, S, HUNTER, A. Christy
Format: Article
Language:English
Subjects:
Animals
Antibodies
Apolipoproteins
Biological and medical sciences
Blood Proteins - metabolism
Cell physiology
Endocytosis
Fundamental and applied biological sciences. Psychology
General pharmacology
Hepatocytes - immunology
Hepatocytes - metabolism
Humans
Immunoglobulins
Liposomes - immunology
Liposomes - metabolism
Liver
Macrophages - immunology
Macrophages - metabolism
Medical sciences
Molecular and cellular biology
Opsonin Proteins - immunology
Opsonin Proteins - metabolism
Pharmaceutical technology. Pharmaceutical industry
Pharmacokinetics
Pharmacology. Drug treatments
Phospholipids - immunology
Phospholipids - metabolism
Plasma
Proteins
Receptors, Immunologic - metabolism
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Summary:The interaction of liposomes with blood proteins is believed to play a critical role in the clearance pharmacokinetics and tissue distribution of intravenously injected liposomes. In this article we have focused our discussion on the interaction of liposomes with key blood proteins, which include immunoglobulins, complement proteins, apolipoproteins, fetuin, von Willebrand factor, and thrombospondin, and their role in liposome recognition by professional phagocytes and nonmacrophage hepatic cells. Alternatively, macrophages as well as hepatocytes and liver endothelial cells may phagocytose/endocytose liposomes via direct recognition of phospholipid headgroups. A number of plasma membrane receptors such as lectin receptors, CD14, various classes of scavenger receptors (e.g., classes A, B, and D), Fc-gammaRI and FcgammaRII-B2 may participate in phospholipid recognition. These concepts are also discussed.
ISSN:0724-8741
1573-904X
DOI:10.1023/A:1011054123304