Use of omeprazole in the management of giant duodenal ulcer: Results of a prospective study

• Published in: Surgery 1999-10, Vol.126 (4), p.643-649
• Main Authors: Fischer, David R., Nussbaum, Michael S., Pritts, Timothy A., Gilinsky, Norman H., Weesner, Robert E., Martin, Stephen P., Giannella, Ralph A.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents - administration & dosage; Biopsy; Duodenal Ulcer - drug therapy; Duodenal Ulcer - microbiology; Duodenal Ulcer - pathology; Female; Gastroscopy; Helicobacter Infections - complications; Helicobacter Infections - pathology; Helicobacter pylori; Humans; Male; Middle Aged; Omeprazole - administration & dosage; Prospective Studies; Recurrence; Treatment Outcome
• ISSN: 0039-6060; 1532-7361
• DOI: 10.1016/S0039-6060(99)70117-0

Background: Giant duodenal ulcer (GDU) is generally thought to require surgical intervention. Proton pump inhibitors have beneficial effects in peptic ulcer disease, but their role in GDU disease is unknown. We examined the use of omeprazole in GDU management. Methods: Twenty-eight patients were diagnosed with GDU. One patient required immediate operative intervention. The remaining 27 were placed on omeprazole (40 mg daily). When ulcer healing was documented by endoscopy, the patients were placed on oral histamine-2 receptor antagonist therapy. Results: Of the 28 study patients, 20 (71.4%) did not require operative intervention, and 8 (28.6%) required operation for ulcer complications. Of the 15 patients with adherent clot or a visible vessel at initial endoscopy, 7 (46.7%) required operative intervention, as compared with 1 (7.7%) of the 13 patients without a visible vessel or adherent clot. This difference was statistically significant ( P < .05). Twenty-three patients underwent antral biopsy and/or enzyme-linked immunosorbent assay for Helicobacter pylori, and 9 (39.1%) had a positive result. Conclusions: Omeprazole is effective in the treatment of GDU disease. An adherent clot or a visible vessel at endoscopy indicates a higher likelihood of complications requiring operation. The relatively low H pylori infection rate, as compared with other peptic ulcer disease, may indicate a different pathophysiology in GDU. (Surgery 1999;126:643-9.)