Role of nitric oxide and lipid peroxidation in mechanisms of febrile convulsions in Wistar rat pups

Generation of nitric oxide and the content of lipid peroxidation products in the brain are increased in rat pups during febrile convulsions. NO-synthase inhibitor N-nitro-L-arginine in a dose of 250 mg/kg prevented hyperthermia-induced accumulation of nitric oxide, increased the latency febrile conv...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2001-01, Vol.131 (1), p.47-49
Main Authors: Klyueva, Y A, Bashkatova, V G, Vitskova, G Y, Narkevich, V B, Mikoyan, V D, Vanin, A F, Chepurnov, S A, Chepurnova, N E
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Cerebral Cortex - metabolism
Electron Spin Resonance Spectroscopy
Enzyme Inhibitors - pharmacology
Lipid Peroxidation
Nitric Oxide - metabolism
Nitric Oxide Synthase - antagonists & inhibitors
Rats
Rats, Wistar
Seizures, Febrile - metabolism
Thiobarbituric Acid Reactive Substances - metabolism
Time Factors
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Summary:Generation of nitric oxide and the content of lipid peroxidation products in the brain are increased in rat pups during febrile convulsions. NO-synthase inhibitor N-nitro-L-arginine in a dose of 250 mg/kg prevented hyperthermia-induced accumulation of nitric oxide, increased the latency febrile convulsions, and had no effect on the content of lipid peroxidation products.
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1017530612936