Prothrombotic state and elevated levels of plasminogen activator inhibitor-1 in mitral stenosis with and without atrial fibrillation

Patients with mitral stenosis in sinus rhythm are in a prothrombotic state and have fibrinolytic dysfunction, shown by an increase in levels of the inhibitor of tissue plasminogen activator, D-dimer, and modified antithrombin III. This state may be observed even in patients without dilated left atri...

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Bibliographic Details
Published in:The American journal of cardiology 1999-10, Vol.84 (7), p.862-864
Main Authors: Marı́n, Francisco, Roldán, Vanessa, Monmeneu, José V, Bodı́, Vicente, Fernández, Cristina, Garcı́a de Burgos, Fernando, Marco, Pascual, Sogorb, Francisco
Format: Article
Language:English
Subjects:
Atrial Fibrillation - complications
Atrial Fibrillation - diagnostic imaging
Atrial Fibrillation - metabolism
Biological and medical sciences
Cardiology. Vascular system
Chemicals
Echocardiography
Effects
Endocardial and cardiac valvular diseases
Female
Fibrin - metabolism
Heart
Humans
Immunoenzyme Techniques
Male
Medical disorders
Medical sciences
Middle Aged
Mitral Valve Stenosis - complications
Mitral Valve Stenosis - diagnostic imaging
Mitral Valve Stenosis - metabolism
Plasminogen Activator Inhibitor 1 - metabolism
Statistics, Nonparametric
Studies
Thrombin - metabolism
Tissue Plasminogen Activator - metabolism
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Description
Summary:Patients with mitral stenosis in sinus rhythm are in a prothrombotic state and have fibrinolytic dysfunction, shown by an increase in levels of the inhibitor of tissue plasminogen activator, D-dimer, and modified antithrombin III. This state may be observed even in patients without dilated left atria (diameter < or =45 mm).
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(99)00453-1