Multi-faceted regulation of γ-glutamylcysteine synthetase

Glutathione is an important antioxidant that is involved in numerous cellular activities. γ‐Glutamylcysteine synthetase (γGCS) is a key regulatory enzyme in the synthesis of glutathione. It is a heterodimeric zinc metalloprotein that belongs to a unique class of proteins that gain activity due to fo...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cellular physiology 2000-02, Vol.182 (2), p.163-170
Main Authors: Soltaninassab, Syrus R., Sekhar, Konjeti R., Meredith, Michael J., Freeman, Michael L.
Format: Article
Language:English
Subjects:
Amino Acid Sequence - genetics
Animals
Cell Physiological Phenomena
Chromosome Mapping
Disease
Gene Expression Regulation - physiology
Glutamate-Cysteine Ligase - genetics
Glutamate-Cysteine Ligase - metabolism
Glutathione - biosynthesis
Glutathione - physiology
Humans
Isoenzymes - genetics
Isoenzymes - metabolism
Molecular Sequence Data
Transcription, Genetic - physiology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Glutathione is an important antioxidant that is involved in numerous cellular activities. γ‐Glutamylcysteine synthetase (γGCS) is a key regulatory enzyme in the synthesis of glutathione. It is a heterodimeric zinc metalloprotein that belongs to a unique class of proteins that gain activity due to formation of a reversible disulfide bond. The two subunits of γGCS exhibit differential and coordinate transcription regulation. In addition, the subunits are regulated at the posttranscriptional and posttranslational levels. These various levels of regulation allow numerous stimuli to induce or inhibit activity. J. Cell. Physiol. 182:163–170, 2000. © 2000 Wiley‐Liss, Inc.
ISSN:0021-9541
1097-4652
DOI:10.1002/(SICI)1097-4652(200002)182:2<163::AID-JCP4>3.0.CO;2-1