Antimicrobial alkaloids from Zanthoxylum tetraspermum and caudatum

Two benzophenanthrene alkaloids, 8-acetonyldihydronitidine and 8-acetonyldihydroavicine were isolated from Zanthoxylum tetraspermum stem bark along with liriodenine, sesamin, lichexanthone and (+)-piperitol-gamma,gamma-dimethylallylether. The species endemic to Sri Lanka, Z. caudatum, contained sesa...

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Bibliographic Details
Published in:Phytochemistry (Oxford) 2001-04, Vol.56 (8), p.857-861
Main Authors: NISSANKA, Ajith P. K, KARUNARATNE, Veranja, RATNAYAKE BANDARA, B. M, KUMAR, Vijaya, NAKANISHI, Tsutomu, NISHI, Masatoshi, INADA, Akira, TILLEKERATNE, L. M. V, WIJESUNDARA, D. S. A, GUNATILAKA, A. A
Format: Article
Language:English
Subjects:
8-acetonyldihydroavicine
8-acetonyldihydronitidine
alkaloids
Alkaloids - chemistry
Alkaloids - isolation & purification
Alkaloids - pharmacology
Anti-Infective Agents - chemistry
Anti-Infective Agents - isolation & purification
benzophenanthrene
Biological and medical sciences
Chemical constitution
Fundamental and applied biological sciences. Psychology
General pharmacology
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phenanthrenes - chemistry
Phenanthrenes - isolation & purification
Phenanthrenes - pharmacology
Plant physiology and development
Rosales - chemistry
Zanthoxylum tetraspermum
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Summary:Two benzophenanthrene alkaloids, 8-acetonyldihydronitidine and 8-acetonyldihydroavicine were isolated from Zanthoxylum tetraspermum stem bark along with liriodenine, sesamin, lichexanthone and (+)-piperitol-gamma,gamma-dimethylallylether. The species endemic to Sri Lanka, Z. caudatum, contained sesamin, savinin, liriodenine, decarine and 8-O-desmethyl-N-nornitidine. 8-Acetonyldihydronitidine and 8-acetonyldihydroavicine showed significant antibacterial activity while the former along with liriodenine was strongly antifungal. Savinin exhibited potent spermicidal activity. Both savinin and sesamin exhibited significant insecticidal activity.
ISSN:0031-9422
1873-3700
DOI:10.1016/S0031-9422(00)00402-7