An international survey of practice variation in the use of antibiotic prophylaxis in cesarean section

Objective: To examine the use of antibiotic prophylaxis in cesarean section in different countries and in relation to a reference regimen. Method: Fifty consecutive cesarean sections performed in eight centers in five countries were surveyed. Data from each center were compared to a regimen recommen...

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Bibliographic Details
Published in:International journal of gynecology and obstetrics 2001-05, Vol.73 (2), p.141-145
Main Authors: Huskins, W.C., Ba-Thike, K., Festin, M.R., Limpongsanurak, S., Lumbiganon, P., Peedicayil, A., Purwar, M., Shenoy, S., Goldmann, D.A., Tolosa, J.E.
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotic prophylaxis
Antibiotic Prophylaxis - statistics & numerical data
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Cesarean section
Cesarean Section - methods
Female
Guideline Adherence
Humans
India
Medical sciences
Myanmar
Pharmacology. Drug treatments
Philippines
Physician's practice patterns
Practice Guidelines as Topic
Practice Patterns, Physicians' - statistics & numerical data
Pregnancy
Surgical Wound Infection - prevention & control
Thailand
United States
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Summary:Objective: To examine the use of antibiotic prophylaxis in cesarean section in different countries and in relation to a reference regimen. Method: Fifty consecutive cesarean sections performed in eight centers in five countries were surveyed. Data from each center were compared to a regimen recommended by the Cochrane Collaboration (one dose of ampicillin or cefazolin administered to all women shortly before the procedure or immediately after cord clamping) using logistic regression with adjustment for procedure type. Result: Prophylaxis was used widely, but only four centers administered prophylaxis to all women. Ampicillin and cefazolin were the principal antibiotics used, but broad-spectrum agents and multidrug regimens were also used commonly. Only two centers reliably administered the antibiotic at the appropriate time. The majority of women received only one dose of antibiotic in only three centers. Conclusion: The use of antibiotic prophylaxis in cesarean section was variable and often at odds with published recommendations.
ISSN:0020-7292
1879-3479
DOI:10.1016/S0020-7292(01)00365-4