Protein kinase C isoenzyme: selective expression pattern of protein kinase C-θ during mouse development

• Published in: Mechanisms of development 2001-05, Vol.103 (1), p.197-200
• Main Authors: Wilda, Monika, Ghaffari-Tabrizi, Nassim, Reisert, Ingrid, Utermann, Gerd, Baier, Gottfried, Hameister, Horst
• Format: Article
• Language: English
• Subjects: Afferent neuronal conduction; Alar plate; Amygdaloid area; Animals; Brain - embryology; Cerebellum; Cerebellum - embryology; Choroid plexus; DNA, Complementary - metabolism; Dorsal root ganglia; Gene Expression; Gracile and cuneate fasciculi; Hematopoiesis; Interneuron layer of praepiriform cortex; Isoenzymes - biosynthesis; Liver; Lymphopoiesis; Medial habenulae; Medial lemniscus; Mice; Mice, Inbred C57BL; Mitral cell layer of olfactory bulb; Olfactory system; Protein Kinase C - biosynthesis; Protein Kinase C-theta; Protein kinase C-θ; RNA in situ hybridization; Spleen; Thalamus; Thymus; Tissue Distribution; Trigeminal and facial ganglia; Yolk sac
• ISSN: 0925-4773; 1872-6356
• DOI: 10.1016/S0925-4773(01)00357-4

Protein kinase C (PKC)-θ, a serine/threonine protein kinase and novel PKC subfamily member, has been recently identified as an essential component of the T cell synapse which activates the NF-kB signaling cascade leading to expression of the IL-2 gene during T cell activation. By RNA in situ hybridization to whole-body embryo sections it is shown that the murine PKCθ is specifically expressed in tissues with hematopoietic and lymphopoietic activity. Expression is also evident in skeletal muscle. A further highly specific expression was observed in the peripheral and central nervous system which is described in detail. Expression in the brain persists up to adult stages.