Differential expression and function of the Drosophila Pax6 genes eyeless and twin of eyeless in embryonic central nervous system development

We analyzed the expression and function of eyeless (ey) and twin of eyeless (toy) in the embryonic central nervous system (CNS) of Drosophila. Both genes are differentially expressed in specific neuronal subsets (but not in glia) in every CNS neuromere, and in the brain, specific cell populations co...

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Bibliographic Details
Published in:Mechanisms of development 2001-05, Vol.103 (1-2), p.71-78
Main Authors: Kammermeier, L, Leemans, R, Hirth, F, Flister, S, Wenger, U, Walldorf, U, Gehring, W J, Reichert, H
Format: Article
Language:English
Subjects:
Alleles
Animals
Central Nervous System - embryology
Crosses, Genetic
DNA-Binding Proteins - biosynthesis
DNA-Binding Proteins - physiology
Drosophila - embryology
Drosophila Proteins
Eye Proteins
Homeodomain Proteins - biosynthesis
Homeodomain Proteins - physiology
Immunohistochemistry
In Situ Hybridization
Microscopy, Confocal
Paired Box Transcription Factors
PAX6 Transcription Factor
Protein Structure, Tertiary
Repressor Proteins
RNA, Double-Stranded - metabolism
Tissue Distribution
Trans-Activators - biosynthesis
Trans-Activators - physiology
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Summary:We analyzed the expression and function of eyeless (ey) and twin of eyeless (toy) in the embryonic central nervous system (CNS) of Drosophila. Both genes are differentially expressed in specific neuronal subsets (but not in glia) in every CNS neuromere, and in the brain, specific cell populations co-expressing both proteins define a longitudinal domain which is intercalated between broad exclusive expression domains of ey and toy. Studies of genetic null alleles and dsRNA interference did not reveal any gross neuroanatomical effects of ey, toy, or ey/toy elimination in the embryonic CNS. In contrast, targeted misexpression of ey, but not of toy, resulted in profound axonal abnormalities in the embryonic ventral nerve cord and brain.
ISSN:0925-4773
DOI:10.1016/S0925-4773(01)00328-8