Primary Brain Lymphoma Cell Turnover Differs in Patients With and Without AIDS: Relationships to bcl-2 Expression and Host Cell Reaction

• Published in: Journal of neuropathology and experimental neurology 1999-10, Vol.58 (10), p.1069-1077
• Main Authors: Christov, C, Adle-Biassette, H, Lechapt, E, Poron, F, Gray, F, Gaulard, P, Gherardi, R K
• Format: Article
• Language: English
• Subjects: AIDS (Disease); AIDS/HIV; Apoptosis; Biological and medical sciences; Brain Neoplasms - pathology; Care and treatment; Cell Count; Cell Division; Chemotherapy; Comparative analysis; Hematologic and hematopoietic diseases; Human viral diseases; Humans; Infectious diseases; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphocytes, Tumor-Infiltrating - pathology; Lymphoma - pathology; Lymphoma, AIDS-Related - pathology; Lymphomas; Macrophages - pathology; Medical sciences; Proto-Oncogene Proteins c-bcl-2 - metabolism; RNA, Viral - metabolism; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral Matrix Proteins - metabolism
• ISSN: 0022-3069; 1554-6578
• DOI: 10.1097/00005072-199910000-00005

Primary central nervous system lymphomas (PCNSLs) are more resistant to radiotherapy and chemotherapy in AIDS (A-PCNSLs) than in non-AIDS patients (NA-PCNSLs). We investigated 23 A-PCNSLs and 24 NA-PCNSLs. Lymphoma cell kinetics (i.e. proliferation [mitotic index, MIB-1 and PCNA labeling indices], apoptosis and turnover) were determined and compared with bcl-2 and LMP-1 expression, and to the percentage of tumor-infiltrating T-lymphocytes (T-TILs) and macrophages. A-PCNSLs showed lower proliferation (p