Transporters in African trypanosomes : role in drug action and resistance

Sleeping sickness is an increasing problem in many parts of sub-Saharan Africa. The problems are compounded by the lack of new medication, and the increasing resistance against traditional drugs such as melarsoprol, berenil and isometamidium. Over the last few years, much progress has been made in u...

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Bibliographic Details
Published in:International journal for parasitology 2001-05, Vol.31 (5-6), p.512-522
Main Author: DE KONING, Harry P
Format: Article
Language:English
Subjects:
Africa
Africa South of the Sahara
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiparasitic agents
Arsenicals - pharmacokinetics
Biological and medical sciences
Biological Transport
Eflornithine - pharmacokinetics
Humans
Medical sciences
Nitroimidazoles - pharmacokinetics
Pentamidine - pharmacokinetics
Pharmacology. Drug treatments
Phenanthridines - pharmacokinetics
Suramin - pharmacokinetics
Trypanocidal Agents - pharmacokinetics
Trypanocidal Agents - pharmacology
Trypanosoma
Trypanosoma - drug effects
Trypanosoma - metabolism
Trypanosomiasis, African - drug therapy
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Summary:Sleeping sickness is an increasing problem in many parts of sub-Saharan Africa. The problems are compounded by the lack of new medication, and the increasing resistance against traditional drugs such as melarsoprol, berenil and isometamidium. Over the last few years, much progress has been made in understanding how drug action, and the development of resistance, is related to the mechanisms by which the parasite ingests the drugs. In some cases novel transporters have been identified. In other cases, transporters do not appear to be involved in drug uptake, and selectivity must lie with other parasite features, such as a specific target or activation of the drug. Lessons learned from studying the uptake of drugs currently in use may assist the design of a much needed new generation of trypanocides.
ISSN:0020-7519
1879-0135
DOI:10.1016/S0020-7519(01)00167-9