Endothelin-1 contributes to normocapnic hyperoxic pial artery vasoconstriction

• Published in: Brain research 1999-09, Vol.842 (1), p.252-255
• Main Author: Armstead, William M
• Format: Article
• Language: English
• Subjects: Animals; Arterioles - anatomy & histology; Arterioles - drug effects; Biological and medical sciences; Blood Pressure - drug effects; Carbon Dioxide - metabolism; Cerebral Arteries - drug effects; Cerebral Arteries - physiology; Cerebral circulation; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges; Endothelin; Endothelin-1 - metabolism; Endothelin-1 - physiology; Female; Fundamental and applied biological sciences. Psychology; Hyperoxia; Hyperoxia - metabolism; Hyperoxia - physiopathology; Male; Newborn; normocapnia; pial artery; Space life sciences; Swine; Vasoconstriction - drug effects; Vasoconstriction - physiology; Vertebrates: nervous system and sense organs
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/S0006-8993(99)01825-9

The present study was designed to determine if hyperoxia elicits pial artery vasoconstriction and to characterize the contribution of endothelin-1 (ET-1) to that vascular response in newborn pigs equipped with a closed cranial window. Hyperoxic conditions were established by ventilating the piglets with 100% O 2 during normocapnia and concomitantly topically applying artificial CSF that had been bubbled with 100% O 2. Hyperoxia elevated CSF ET-1 from 23±1 to 45±4 pg/ml. Hyperoxia also elicited pial artery vasoconstriction that was attenuated by BQ123 (10 −6 M), an ET-1 antagonist (−15±1 vs. −5±1%). These data indicate that ET-1 contributes to hyperoxic pial artery vasoconstriction.