Metrifonate improves working but not reference memory performance in a spatial cone field task

The effects of metrifonate (3, 10 and 30 mg/kg, p.o.) on the working and reference memory performance of the rat were assessed in a spatial cone field task. The highest dose of metrifonate (30 mg/kg) improved the working memory performance, whereas none of the doses affected the reference memory per...

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Bibliographic Details
Published in:European journal of pharmacology 1999-09, Vol.380 (2), p.61-65
Main Authors: Prickaerts, Jos, Honig, Wiel, Schmidt, Bernard H, Blokland, Arjan
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cholinesterase Inhibitors - pharmacology
Cone field
Discrimination Learning - drug effects
Male
Medical sciences
Memory
Memory - drug effects
Metrifonate
Neuropharmacology
Neuroprotective agent
Pharmacology. Drug treatments
Rat
Rats
Rats, Wistar
Spatial
Spatial Behavior - drug effects
Task Performance and Analysis
Trichlorfon - pharmacology
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Summary:The effects of metrifonate (3, 10 and 30 mg/kg, p.o.) on the working and reference memory performance of the rat were assessed in a spatial cone field task. The highest dose of metrifonate (30 mg/kg) improved the working memory performance, whereas none of the doses affected the reference memory performance. Other parameters of spatial discrimination performance were not affected by metrifonate treatment. The present results suggest that metrifonate has cognition-enhancing properties which are likely to be related to aspects of (spatial) working memory.
ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(99)00565-8