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Metrifonate improves working but not reference memory performance in a spatial cone field task

The effects of metrifonate (3, 10 and 30 mg/kg, p.o.) on the working and reference memory performance of the rat were assessed in a spatial cone field task. The highest dose of metrifonate (30 mg/kg) improved the working memory performance, whereas none of the doses affected the reference memory per...

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Published in:	European journal of pharmacology 1999-09, Vol.380 (2), p.61-65
Main Authors:	Prickaerts, Jos, Honig, Wiel, Schmidt, Bernard H, Blokland, Arjan
Format:	Article
Language:	English
Subjects:	Animals Biological and medical sciences Cholinesterase Inhibitors - pharmacology Cone field Discrimination Learning - drug effects Male Medical sciences Memory Memory - drug effects Metrifonate Neuropharmacology Neuroprotective agent Pharmacology. Drug treatments Rat Rats Rats, Wistar Spatial Spatial Behavior - drug effects Task Performance and Analysis Trichlorfon - pharmacology
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container_end_page	65
container_issue	2
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container_title	European journal of pharmacology
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creator	Prickaerts, Jos Honig, Wiel Schmidt, Bernard H Blokland, Arjan
description	The effects of metrifonate (3, 10 and 30 mg/kg, p.o.) on the working and reference memory performance of the rat were assessed in a spatial cone field task. The highest dose of metrifonate (30 mg/kg) improved the working memory performance, whereas none of the doses affected the reference memory performance. Other parameters of spatial discrimination performance were not affected by metrifonate treatment. The present results suggest that metrifonate has cognition-enhancing properties which are likely to be related to aspects of (spatial) working memory.
doi_str_mv	10.1016/S0014-2999(99)00565-8
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subjects	Animals Biological and medical sciences Cholinesterase Inhibitors - pharmacology Cone field Discrimination Learning - drug effects Male Medical sciences Memory Memory - drug effects Metrifonate Neuropharmacology Neuroprotective agent Pharmacology. Drug treatments Rat Rats Rats, Wistar Spatial Spatial Behavior - drug effects Task Performance and Analysis Trichlorfon - pharmacology
title	Metrifonate improves working but not reference memory performance in a spatial cone field task
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