Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals

Cellular survival of endoplasmic reticulum stress requires the unfolded protein response (UPR), a stress response first elucidated genetically in yeast. While we continue to refine our knowledge of the yeast system, especially the breadth and significance of the transcriptional response, conservatio...

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Bibliographic Details
Published in:Current Opinion in Cell Biology 2001-06, Vol.13 (3), p.349-355
Main Authors: Patil, Chris, Walter, Peter
Format: Article
Language:English
Subjects:
Animals
Apoptosis - physiology
ATF6
Cell Nucleus - metabolism
eIF-2 Kinase - metabolism
Endoplasmic Reticulum - metabolism
Endoribonucleases
Evolution, Molecular
Fungal Proteins - genetics
Fungal Proteins - metabolism
Genetic Variation
Humans
Mammals - metabolism
Membrane Glycoproteins - genetics
Membrane Glycoproteins - metabolism
Membrane Proteins
Protein Biosynthesis - genetics
Protein Biosynthesis - physiology
Protein Folding
protein folding HAC1
Protein-Serine-Threonine Kinases - genetics
Protein-Serine-Threonine Kinases - metabolism
Saccharomyces cerevisiae Proteins
Signal Transduction - physiology
Transcription, Genetic - genetics
Transcription, Genetic - physiology
unfolded protein response
yeast
Yeasts - metabolism
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Summary:Cellular survival of endoplasmic reticulum stress requires the unfolded protein response (UPR), a stress response first elucidated genetically in yeast. While we continue to refine our knowledge of the yeast system, especially the breadth and significance of the transcriptional response, conservation of the system's elements has allowed identification of corresponding and additional components of the mammalian UPR. Recent results reveal that the output of the mammalian UPR reaches beyond transcriptional regulation of secretory pathway components to control of general translation, the cell cycle and programmed cell death.
ISSN:0955-0674
1879-0410
DOI:10.1016/S0955-0674(00)00219-2