Loading…
Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals
Cellular survival of endoplasmic reticulum stress requires the unfolded protein response (UPR), a stress response first elucidated genetically in yeast. While we continue to refine our knowledge of the yeast system, especially the breadth and significance of the transcriptional response, conservatio...
Saved in:
| Published in: | Current Opinion in Cell Biology 2001-06, Vol.13 (3), p.349-355 |
|---|---|
| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c510t-9e5ebd4568f0ff03406a6a6cca6a674c31b2e41a2653b6cc8b07755cc8f6de223 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c510t-9e5ebd4568f0ff03406a6a6cca6a674c31b2e41a2653b6cc8b07755cc8f6de223 |
| container_end_page | 355 |
| container_issue | 3 |
| container_start_page | 349 |
| container_title | Current Opinion in Cell Biology |
| container_volume | 13 |
| creator | Patil, Chris Walter, Peter |
| description | Cellular survival of endoplasmic reticulum stress requires the unfolded protein response (UPR), a stress response first elucidated genetically in yeast. While we continue to refine our knowledge of the yeast system, especially the breadth and significance of the transcriptional response, conservation of the system's elements has allowed identification of corresponding and additional components of the mammalian UPR. Recent results reveal that the output of the mammalian UPR reaches beyond transcriptional regulation of secretory pathway components to control of general translation, the cell cycle and programmed cell death. |
| doi_str_mv | 10.1016/S0955-0674(00)00219-2 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70823436</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0955067400002192</els_id><sourcerecordid>70823436</sourcerecordid><originalsourceid>FETCH-LOGICAL-c510t-9e5ebd4568f0ff03406a6a6cca6a674c31b2e41a2653b6cc8b07755cc8f6de223</originalsourceid><addsrcrecordid>eNqFkd9PHCEQx0mjqee1f0Ibnox9WB12l_3RF2NMrSYmPrR9JizMKoaFKywm99_L3l3aR0PCDMxnmGG-hHxhcMGANZe_oOe8gKatzwG-AZSsL8oPZMW6ti-gZnBEVv-QE3Ia4wsANFD2H8kJY1Vd9dCuyPbezUEqtDZZGWg0T05a457oGPxE52ek6LTfWBkno2jA2ahkU474XdAlZTHF77tDcqO3GjXdBD-jcRmPG-8i0uxvUcaZSqfpJKdJ2viJHI_Z4OeDXZM_tz9-39wVD48_72-uHwrFGcxFjxwHXfOmG2EcoaqhkXkptextrSo2lFgzWTa8GvJ1N0Dbcp6dsdFYltWanO3fzV39TRhnMZm4fFg69CmKFroyT6N5F2Rt11d1zzPI96AKPsaAo9gEM8mwFQzEIo7YiSOWyQsAsRNHLJ18PRRIw4T6f9ZBjQxc7QHM83g1GERUBp1CbQKqWWhv3inxBrhqoP8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17893495</pqid></control><display><type>article</type><title>Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals</title><source>ScienceDirect Freedom Collection 2022-2024</source><creator>Patil, Chris ; Walter, Peter</creator><creatorcontrib>Patil, Chris ; Walter, Peter</creatorcontrib><description>Cellular survival of endoplasmic reticulum stress requires the unfolded protein response (UPR), a stress response first elucidated genetically in yeast. While we continue to refine our knowledge of the yeast system, especially the breadth and significance of the transcriptional response, conservation of the system's elements has allowed identification of corresponding and additional components of the mammalian UPR. Recent results reveal that the output of the mammalian UPR reaches beyond transcriptional regulation of secretory pathway components to control of general translation, the cell cycle and programmed cell death.</description><identifier>ISSN: 0955-0674</identifier><identifier>EISSN: 1879-0410</identifier><identifier>DOI: 10.1016/S0955-0674(00)00219-2</identifier><identifier>PMID: 11343907</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Apoptosis - physiology ; ATF6 ; Cell Nucleus - metabolism ; eIF-2 Kinase - metabolism ; Endoplasmic Reticulum - metabolism ; Endoribonucleases ; Evolution, Molecular ; Fungal Proteins - genetics ; Fungal Proteins - metabolism ; Genetic Variation ; Humans ; Mammals - metabolism ; Membrane Glycoproteins - genetics ; Membrane Glycoproteins - metabolism ; Membrane Proteins ; Protein Biosynthesis - genetics ; Protein Biosynthesis - physiology ; Protein Folding ; protein folding HAC1 ; Protein-Serine-Threonine Kinases - genetics ; Protein-Serine-Threonine Kinases - metabolism ; Saccharomyces cerevisiae Proteins ; Signal Transduction - physiology ; Transcription, Genetic - genetics ; Transcription, Genetic - physiology ; unfolded protein response ; yeast ; Yeasts - metabolism</subject><ispartof>Current Opinion in Cell Biology, 2001-06, Vol.13 (3), p.349-355</ispartof><rights>2001 Elsevier Science Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-9e5ebd4568f0ff03406a6a6cca6a674c31b2e41a2653b6cc8b07755cc8f6de223</citedby><cites>FETCH-LOGICAL-c510t-9e5ebd4568f0ff03406a6a6cca6a674c31b2e41a2653b6cc8b07755cc8f6de223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>313,314,780,784,792,27920,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11343907$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patil, Chris</creatorcontrib><creatorcontrib>Walter, Peter</creatorcontrib><title>Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals</title><title>Current Opinion in Cell Biology</title><addtitle>Curr Opin Cell Biol</addtitle><description>Cellular survival of endoplasmic reticulum stress requires the unfolded protein response (UPR), a stress response first elucidated genetically in yeast. While we continue to refine our knowledge of the yeast system, especially the breadth and significance of the transcriptional response, conservation of the system's elements has allowed identification of corresponding and additional components of the mammalian UPR. Recent results reveal that the output of the mammalian UPR reaches beyond transcriptional regulation of secretory pathway components to control of general translation, the cell cycle and programmed cell death.</description><subject>Animals</subject><subject>Apoptosis - physiology</subject><subject>ATF6</subject><subject>Cell Nucleus - metabolism</subject><subject>eIF-2 Kinase - metabolism</subject><subject>Endoplasmic Reticulum - metabolism</subject><subject>Endoribonucleases</subject><subject>Evolution, Molecular</subject><subject>Fungal Proteins - genetics</subject><subject>Fungal Proteins - metabolism</subject><subject>Genetic Variation</subject><subject>Humans</subject><subject>Mammals - metabolism</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Membrane Glycoproteins - metabolism</subject><subject>Membrane Proteins</subject><subject>Protein Biosynthesis - genetics</subject><subject>Protein Biosynthesis - physiology</subject><subject>Protein Folding</subject><subject>protein folding HAC1</subject><subject>Protein-Serine-Threonine Kinases - genetics</subject><subject>Protein-Serine-Threonine Kinases - metabolism</subject><subject>Saccharomyces cerevisiae Proteins</subject><subject>Signal Transduction - physiology</subject><subject>Transcription, Genetic - genetics</subject><subject>Transcription, Genetic - physiology</subject><subject>unfolded protein response</subject><subject>yeast</subject><subject>Yeasts - metabolism</subject><issn>0955-0674</issn><issn>1879-0410</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqFkd9PHCEQx0mjqee1f0Ibnox9WB12l_3RF2NMrSYmPrR9JizMKoaFKywm99_L3l3aR0PCDMxnmGG-hHxhcMGANZe_oOe8gKatzwG-AZSsL8oPZMW6ti-gZnBEVv-QE3Ia4wsANFD2H8kJY1Vd9dCuyPbezUEqtDZZGWg0T05a457oGPxE52ek6LTfWBkno2jA2ahkU474XdAlZTHF77tDcqO3GjXdBD-jcRmPG-8i0uxvUcaZSqfpJKdJ2viJHI_Z4OeDXZM_tz9-39wVD48_72-uHwrFGcxFjxwHXfOmG2EcoaqhkXkptextrSo2lFgzWTa8GvJ1N0Dbcp6dsdFYltWanO3fzV39TRhnMZm4fFg69CmKFroyT6N5F2Rt11d1zzPI96AKPsaAo9gEM8mwFQzEIo7YiSOWyQsAsRNHLJ18PRRIw4T6f9ZBjQxc7QHM83g1GERUBp1CbQKqWWhv3inxBrhqoP8</recordid><startdate>20010601</startdate><enddate>20010601</enddate><creator>Patil, Chris</creator><creator>Walter, Peter</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>20010601</creationdate><title>Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals</title><author>Patil, Chris ; Walter, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-9e5ebd4568f0ff03406a6a6cca6a674c31b2e41a2653b6cc8b07755cc8f6de223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Apoptosis - physiology</topic><topic>ATF6</topic><topic>Cell Nucleus - metabolism</topic><topic>eIF-2 Kinase - metabolism</topic><topic>Endoplasmic Reticulum - metabolism</topic><topic>Endoribonucleases</topic><topic>Evolution, Molecular</topic><topic>Fungal Proteins - genetics</topic><topic>Fungal Proteins - metabolism</topic><topic>Genetic Variation</topic><topic>Humans</topic><topic>Mammals - metabolism</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Membrane Glycoproteins - metabolism</topic><topic>Membrane Proteins</topic><topic>Protein Biosynthesis - genetics</topic><topic>Protein Biosynthesis - physiology</topic><topic>Protein Folding</topic><topic>protein folding HAC1</topic><topic>Protein-Serine-Threonine Kinases - genetics</topic><topic>Protein-Serine-Threonine Kinases - metabolism</topic><topic>Saccharomyces cerevisiae Proteins</topic><topic>Signal Transduction - physiology</topic><topic>Transcription, Genetic - genetics</topic><topic>Transcription, Genetic - physiology</topic><topic>unfolded protein response</topic><topic>yeast</topic><topic>Yeasts - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patil, Chris</creatorcontrib><creatorcontrib>Walter, Peter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Current Opinion in Cell Biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patil, Chris</au><au>Walter, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals</atitle><jtitle>Current Opinion in Cell Biology</jtitle><addtitle>Curr Opin Cell Biol</addtitle><date>2001-06-01</date><risdate>2001</risdate><volume>13</volume><issue>3</issue><spage>349</spage><epage>355</epage><pages>349-355</pages><issn>0955-0674</issn><eissn>1879-0410</eissn><abstract>Cellular survival of endoplasmic reticulum stress requires the unfolded protein response (UPR), a stress response first elucidated genetically in yeast. While we continue to refine our knowledge of the yeast system, especially the breadth and significance of the transcriptional response, conservation of the system's elements has allowed identification of corresponding and additional components of the mammalian UPR. Recent results reveal that the output of the mammalian UPR reaches beyond transcriptional regulation of secretory pathway components to control of general translation, the cell cycle and programmed cell death.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>11343907</pmid><doi>10.1016/S0955-0674(00)00219-2</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0955-0674 |
| ispartof | Current Opinion in Cell Biology, 2001-06, Vol.13 (3), p.349-355 |
| issn | 0955-0674 1879-0410 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70823436 |
| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Animals Apoptosis - physiology ATF6 Cell Nucleus - metabolism eIF-2 Kinase - metabolism Endoplasmic Reticulum - metabolism Endoribonucleases Evolution, Molecular Fungal Proteins - genetics Fungal Proteins - metabolism Genetic Variation Humans Mammals - metabolism Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Membrane Proteins Protein Biosynthesis - genetics Protein Biosynthesis - physiology Protein Folding protein folding HAC1 Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Saccharomyces cerevisiae Proteins Signal Transduction - physiology Transcription, Genetic - genetics Transcription, Genetic - physiology unfolded protein response yeast Yeasts - metabolism |
| title | Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T13%3A08%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intracellular%20signaling%20from%20the%20endoplasmic%20reticulum%20to%20the%20nucleus:%20the%20unfolded%20protein%20response%20in%20yeast%20and%20mammals&rft.jtitle=Current%20Opinion%20in%20Cell%20Biology&rft.au=Patil,%20Chris&rft.date=2001-06-01&rft.volume=13&rft.issue=3&rft.spage=349&rft.epage=355&rft.pages=349-355&rft.issn=0955-0674&rft.eissn=1879-0410&rft_id=info:doi/10.1016/S0955-0674(00)00219-2&rft_dat=%3Cproquest_cross%3E70823436%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c510t-9e5ebd4568f0ff03406a6a6cca6a674c31b2e41a2653b6cc8b07755cc8f6de223%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=17893495&rft_id=info:pmid/11343907&rfr_iscdi=true |