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TMC-66, a New Endothelin Converting Enzyme Inhibitor Produced by Streptomyces sp. A5008
A new endothelin converting enzyme (ECE) inhibitor, TMC-66 was isolated from the fermentation broth of Streptomyces sp. A5008. The structure of TMC-66 was elucidated by spectroscopic analyses to be a new member of benzo[a]naphthacenequinone class of antibiotics. TMC-66 had a highly selective inhibit...
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| Published in: | Journal of antibiotics 1999/07/25, Vol.52(7), pp.607-612 |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c667t-23278fc279782dc7dc1b91f813e7c8707db80dfdbc8b4deffb5d1671525940333 |
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| container_end_page | 612 |
| container_issue | 7 |
| container_start_page | 607 |
| container_title | Journal of antibiotics |
| container_volume | 52 |
| creator | ASAI, YASUYUKI NONAKA, NOBUAKI SUZUKI, SHIN-ICHI NISHIO, MAKI TAKAHASHI, KOHEI SHIMA, HIDEAKI OHMORI, KENJI OHNUKI, TETSUO KOMATSUBARA, SABURO |
| description | A new endothelin converting enzyme (ECE) inhibitor, TMC-66 was isolated from the fermentation broth of Streptomyces sp. A5008. The structure of TMC-66 was elucidated by spectroscopic analyses to be a new member of benzo[a]naphthacenequinone class of antibiotics. TMC-66 had a highly selective inhibitory activity for ECE with an IC50 value of 2.9μM. Taxonomy of the producing strain is also described. |
| doi_str_mv | 10.7164/antibiotics.52.607 |
| format | article |
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Psychology ; Lung - drug effects ; Lung - enzymology ; Metalloendopeptidases ; Microbiology ; Naphthacenes - chemistry ; Naphthacenes - pharmacology ; Protease Inhibitors - pharmacology ; Rats ; Streptomyces ; Streptomyces - classification ; Streptomyces - metabolism ; TMC-66 ; Trypsin Inhibitors - pharmacology</subject><ispartof>The Journal of Antibiotics, 1999/07/25, Vol.52(7), pp.607-612</ispartof><rights>Japan Antibiotics Research Association</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c667t-23278fc279782dc7dc1b91f813e7c8707db80dfdbc8b4deffb5d1671525940333</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1882,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1968596$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10513839$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ASAI, YASUYUKI</creatorcontrib><creatorcontrib>NONAKA, NOBUAKI</creatorcontrib><creatorcontrib>SUZUKI, SHIN-ICHI</creatorcontrib><creatorcontrib>NISHIO, MAKI</creatorcontrib><creatorcontrib>TAKAHASHI, KOHEI</creatorcontrib><creatorcontrib>SHIMA, HIDEAKI</creatorcontrib><creatorcontrib>OHMORI, KENJI</creatorcontrib><creatorcontrib>OHNUKI, TETSUO</creatorcontrib><creatorcontrib>KOMATSUBARA, SABURO</creatorcontrib><title>TMC-66, a New Endothelin Converting Enzyme Inhibitor Produced by Streptomyces sp. 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Psychology</subject><subject>Lung - drug effects</subject><subject>Lung - enzymology</subject><subject>Metalloendopeptidases</subject><subject>Microbiology</subject><subject>Naphthacenes - chemistry</subject><subject>Naphthacenes - pharmacology</subject><subject>Protease Inhibitors - pharmacology</subject><subject>Rats</subject><subject>Streptomyces</subject><subject>Streptomyces - classification</subject><subject>Streptomyces - metabolism</subject><subject>TMC-66</subject><subject>Trypsin Inhibitors - pharmacology</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqFkUtr3DAUhUVISaZp_kAWRYuSVT3Vw5bkZRjSNjR9QFO6FLJ0nXGwpYmkSZn--tp4SGeXjQS63znncoTQBSVLSUX5wfjcNV3InU3Lii0FkUdoQZWiBS1FfYwWhDBaKMXIKXqd0gMhXHKpTtApJRXlitcL9Pvu66oQ4j02-Bv8wdfehbyGvvN4FfwTxNz5-_H1724AfOPXY14OEf-IwW0tONzs8M8cYZPDsLOQcNos8VVFiHqDXrWmT3C-v8_Qr4_Xd6vPxe33Tzerq9vCCiFzwTiTqrVM1lIxZ6WztKlpqygHaZUk0jWKuNY1VjWlg7ZtKkeFpBWr6pJwzs_Q5ey7ieFxCynroUsW-t54CNukJVFsBMWLIJW8FqWcHNkM2hhSitDqTewGE3eaEj31rg961xXTY--j6O3efdsM4A4kc9Ej8G4PmGRN30bjbZf-c7VQVT1t-WXGHlI29_A8N-NH2B4OoyfJFC_nY9zimbJrEzV4_g_ZGKfS</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>ASAI, YASUYUKI</creator><creator>NONAKA, NOBUAKI</creator><creator>SUZUKI, SHIN-ICHI</creator><creator>NISHIO, MAKI</creator><creator>TAKAHASHI, KOHEI</creator><creator>SHIMA, HIDEAKI</creator><creator>OHMORI, KENJI</creator><creator>OHNUKI, TETSUO</creator><creator>KOMATSUBARA, SABURO</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><general>Japan Antibiotics Research Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1999</creationdate><title>TMC-66, a New Endothelin Converting Enzyme Inhibitor Produced by Streptomyces sp. A5008</title><author>ASAI, YASUYUKI ; NONAKA, NOBUAKI ; SUZUKI, SHIN-ICHI ; NISHIO, MAKI ; TAKAHASHI, KOHEI ; SHIMA, HIDEAKI ; OHMORI, KENJI ; OHNUKI, TETSUO ; KOMATSUBARA, SABURO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c667t-23278fc279782dc7dc1b91f813e7c8707db80dfdbc8b4deffb5d1671525940333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>antibiotics</topic><topic>Antibiotics (antibacterial agents, antifungal agents)</topic><topic>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</topic><topic>Applied microbiology</topic><topic>Aspartic Acid Endopeptidases - antagonists & inhibitors</topic><topic>Biological and medical sciences</topic><topic>Chemical Phenomena</topic><topic>Chemistry, Physical</topic><topic>endothelin converting enzyme</topic><topic>endothelin converting enzyme inhibitors</topic><topic>Endothelin-Converting Enzymes</topic><topic>Enzyme Inhibitors - chemistry</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Fermentation</topic><topic>Fundamental and applied biological sciences. 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| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1999/07/25, Vol.52(7), pp.607-612 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70824036 |
| source | J-STAGE (Japan Science & Technology Information Aggregator, Electronic) - Open Access English articles |
| subjects | Animals antibiotics Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Aspartic Acid Endopeptidases - antagonists & inhibitors Biological and medical sciences Chemical Phenomena Chemistry, Physical endothelin converting enzyme endothelin converting enzyme inhibitors Endothelin-Converting Enzymes Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Fermentation Fundamental and applied biological sciences. Psychology Lung - drug effects Lung - enzymology Metalloendopeptidases Microbiology Naphthacenes - chemistry Naphthacenes - pharmacology Protease Inhibitors - pharmacology Rats Streptomyces Streptomyces - classification Streptomyces - metabolism TMC-66 Trypsin Inhibitors - pharmacology |
| title | TMC-66, a New Endothelin Converting Enzyme Inhibitor Produced by Streptomyces sp. A5008 |
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