Comparison of lymphoid neoplasm classification : A blinded study between a community and an academic setting

The revised European-American classification of lymphoid neoplasms has been reported as reproducible among expert pathologists and feasible in a community setting. We evaluated the reproducibility of lymphoid neoplasm diagnoses between a community and an academic center. We subtyped 188 lymphoid neo...

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Bibliographic Details
Published in:American journal of clinical pathology 2001-05, Vol.115 (5), p.650-655
Main Authors: SIEBERT, James D, HARVEY, Leigh Anne C, FISHKIN, Paul A. S, KNOST, James A, EHSAN, Aamir, SMIR, Bassam N, CRAIG, Fiona E
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Female
Hematology
Hospitals, Community
Hospitals, University
Humans
Immunophenotyping
Investigative techniques, diagnostic techniques (general aspects)
Lymphoma - classification
Lymphoma - diagnosis
Lymphoma - immunology
Male
Medical sciences
Middle Aged
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Reproducibility of Results
Citations: Items that this one cites
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Summary:The revised European-American classification of lymphoid neoplasms has been reported as reproducible among expert pathologists and feasible in a community setting. We evaluated the reproducibility of lymphoid neoplasm diagnoses between a community and an academic center. We subtyped 188 lymphoid neoplasms using revised European-American classification criteria. Clinical findings, histologic or cytologic preparations, paraffin-section immunostains, and flow cytometry data were reviewed as appropriate. Diagnoses were compared only after completion of the study. Lymphoma subtype was concordant for 167 (88.8%) of 188 cases. Discordant cases included 15 B-cell, 2 T-cell, and 4 Hodgkin lymphomas. For B-cell neoplasms, discordance was most often due to classifying diffuse large cell lymphoma as another aggressive subtype of lymphoma (n = 6), marginal zone lymphoma as another subtype (n = 4), or follicle center lymphoma grade II as grade III (n = 3). For Hodgkin disease, discordance was most often due to classifying nodular sclerosis as mixed cellularity type (n = 3). Comparison of community and academic center diagnoses demonstrated high concordance for most revised European-American classification subtypes. Some sources of discordance have been addressed in the new World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues.
ISSN:0002-9173
1943-7722
DOI:10.1309/84VG-PL1V-T547-VC2R