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The −491 TT apolipoprotein E promoter polymorphism is associated with reduced risk for sporadic Alzheimer's disease
Homozygosity for the A allele of the −491 A/T apolipoprotein E (APOE) promoter polymorphism has recently been reported to be associated with sporadic Alzheimer's disease (AD). Two hundred and fifty one patients with AD and an equal number of controls derived from the same region in a Spanish po...
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| Published in: | Neuroscience letters 2001-05, Vol.304 (3), p.204-208 |
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| container_end_page | 208 |
| container_issue | 3 |
| container_start_page | 204 |
| container_title | Neuroscience letters |
| container_volume | 304 |
| creator | Alvarez-Arcaya, Amaya Combarros, Onofre Llorca, Javier Sánchez-Guerra, Marisa Berciano, José Fernández-Luna, José Luis |
| description | Homozygosity for the A allele of the −491 A/T apolipoprotein E (APOE) promoter polymorphism has recently been reported to be associated with sporadic Alzheimer's disease (AD). Two hundred and fifty one patients with AD and an equal number of controls derived from the same region in a Spanish population, were genotyped for −491 A/T and
ε2/
ε3/
ε4 APOE polymorphisms. We did not detect an elevated −491 AA genotype frequency when comparing AD cases to controls. In contrast, persons homozygous for the T allele were at a significantly reduced risk of AD (odds ratio of 0.10,
P=0.006). Multiple logistic regression analysis indicated that the −491 TT polymorphism added information on the risk of AD which was independent of that of the APOE
ε4 allele. |
| doi_str_mv | 10.1016/S0304-3940(01)01790-6 |
| format | article |
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ε2/
ε3/
ε4 APOE polymorphisms. We did not detect an elevated −491 AA genotype frequency when comparing AD cases to controls. In contrast, persons homozygous for the T allele were at a significantly reduced risk of AD (odds ratio of 0.10,
P=0.006). Multiple logistic regression analysis indicated that the −491 TT polymorphism added information on the risk of AD which was independent of that of the APOE
ε4 allele.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/S0304-3940(01)01790-6</identifier><identifier>PMID: 11343837</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>491 A/T polymorphism ; Adult ; Aged ; Aged, 80 and over ; Alleles ; Alzheimer Disease - genetics ; Alzheimer's disease ; Apolipoprotein E ; Apolipoproteins E - genetics ; Biological and medical sciences ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Homozygote ; Humans ; Male ; Medical sciences ; Middle Aged ; Neurology ; Odds Ratio ; Polymorphism, Genetic - physiology ; Polymorphisms ; Promoter Regions, Genetic - genetics ; Reference Values</subject><ispartof>Neuroscience letters, 2001-05, Vol.304 (3), p.204-208</ispartof><rights>2001 Elsevier Science Ireland Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-5c948a0faf3ebf4fcce313237a54156350ce28297e9555d85e90df6c6aa1560e3</citedby><cites>FETCH-LOGICAL-c420t-5c948a0faf3ebf4fcce313237a54156350ce28297e9555d85e90df6c6aa1560e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=959361$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11343837$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alvarez-Arcaya, Amaya</creatorcontrib><creatorcontrib>Combarros, Onofre</creatorcontrib><creatorcontrib>Llorca, Javier</creatorcontrib><creatorcontrib>Sánchez-Guerra, Marisa</creatorcontrib><creatorcontrib>Berciano, José</creatorcontrib><creatorcontrib>Fernández-Luna, José Luis</creatorcontrib><title>The −491 TT apolipoprotein E promoter polymorphism is associated with reduced risk for sporadic Alzheimer's disease</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Homozygosity for the A allele of the −491 A/T apolipoprotein E (APOE) promoter polymorphism has recently been reported to be associated with sporadic Alzheimer's disease (AD). Two hundred and fifty one patients with AD and an equal number of controls derived from the same region in a Spanish population, were genotyped for −491 A/T and
ε2/
ε3/
ε4 APOE polymorphisms. We did not detect an elevated −491 AA genotype frequency when comparing AD cases to controls. In contrast, persons homozygous for the T allele were at a significantly reduced risk of AD (odds ratio of 0.10,
P=0.006). Multiple logistic regression analysis indicated that the −491 TT polymorphism added information on the risk of AD which was independent of that of the APOE
ε4 allele.</description><subject>491 A/T polymorphism</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alleles</subject><subject>Alzheimer Disease - genetics</subject><subject>Alzheimer's disease</subject><subject>Apolipoprotein E</subject><subject>Apolipoproteins E - genetics</subject><subject>Biological and medical sciences</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Homozygote</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Odds Ratio</subject><subject>Polymorphism, Genetic - physiology</subject><subject>Polymorphisms</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Reference Values</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqFkc9u1DAQxi0EotvCI4AsIVE4BGbiOIlPqKrKH6kSB5az5ToTrSFZB09SVJ6AM4_Ik-DtrsqxJ481v88z_j4hniG8QcD67RdQUBXKVPAK8DVgY6CoH4gVtk1ZNKYpH4rVHXIkjpm_AYBGXT0WR4iqUq1qVmJZb0j-_f2nMijXa-mmOIQpTinOFLbyQuZqzHWSuXEzxjRtAo8ysHTM0Qc3Uyd_hnkjE3WLz5cU-LvsY5I8xeS64OXZ8GtDYaR0yrILTI7piXjUu4Hp6eE8EV_fX6zPPxaXnz98Oj-7LHxVwlxob6rWQe96RVd91XtPClWpGqcr1LXS4KlsS9OQ0Vp3rSYDXV_72rncBlIn4uX-3fyNHwvxbMfAnobBbSkubBvI6hLLe0FsDaLRO1DvQZ8ic6LeTimMLt1YBLsLxt4GY3euW0B7G4yts-75YcByNVL3X3VIIgMvDoBj74Y-ua0PfMcZbVSNmXq3pyi7dh0oWfaBttn4kMjPtovhnkX-Aa7BqzM</recordid><startdate>20010525</startdate><enddate>20010525</enddate><creator>Alvarez-Arcaya, Amaya</creator><creator>Combarros, Onofre</creator><creator>Llorca, Javier</creator><creator>Sánchez-Guerra, Marisa</creator><creator>Berciano, José</creator><creator>Fernández-Luna, José Luis</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20010525</creationdate><title>The −491 TT apolipoprotein E promoter polymorphism is associated with reduced risk for sporadic Alzheimer's disease</title><author>Alvarez-Arcaya, Amaya ; Combarros, Onofre ; Llorca, Javier ; Sánchez-Guerra, Marisa ; Berciano, José ; Fernández-Luna, José Luis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-5c948a0faf3ebf4fcce313237a54156350ce28297e9555d85e90df6c6aa1560e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>491 A/T polymorphism</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alleles</topic><topic>Alzheimer Disease - genetics</topic><topic>Alzheimer's disease</topic><topic>Apolipoprotein E</topic><topic>Apolipoproteins E - genetics</topic><topic>Biological and medical sciences</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Homozygote</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Odds Ratio</topic><topic>Polymorphism, Genetic - physiology</topic><topic>Polymorphisms</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Reference Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alvarez-Arcaya, Amaya</creatorcontrib><creatorcontrib>Combarros, Onofre</creatorcontrib><creatorcontrib>Llorca, Javier</creatorcontrib><creatorcontrib>Sánchez-Guerra, Marisa</creatorcontrib><creatorcontrib>Berciano, José</creatorcontrib><creatorcontrib>Fernández-Luna, José Luis</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alvarez-Arcaya, Amaya</au><au>Combarros, Onofre</au><au>Llorca, Javier</au><au>Sánchez-Guerra, Marisa</au><au>Berciano, José</au><au>Fernández-Luna, José Luis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The −491 TT apolipoprotein E promoter polymorphism is associated with reduced risk for sporadic Alzheimer's disease</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2001-05-25</date><risdate>2001</risdate><volume>304</volume><issue>3</issue><spage>204</spage><epage>208</epage><pages>204-208</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Homozygosity for the A allele of the −491 A/T apolipoprotein E (APOE) promoter polymorphism has recently been reported to be associated with sporadic Alzheimer's disease (AD). Two hundred and fifty one patients with AD and an equal number of controls derived from the same region in a Spanish population, were genotyped for −491 A/T and
ε2/
ε3/
ε4 APOE polymorphisms. We did not detect an elevated −491 AA genotype frequency when comparing AD cases to controls. In contrast, persons homozygous for the T allele were at a significantly reduced risk of AD (odds ratio of 0.10,
P=0.006). Multiple logistic regression analysis indicated that the −491 TT polymorphism added information on the risk of AD which was independent of that of the APOE
ε4 allele.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>11343837</pmid><doi>10.1016/S0304-3940(01)01790-6</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 2001-05, Vol.304 (3), p.204-208 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | 491 A/T polymorphism Adult Aged Aged, 80 and over Alleles Alzheimer Disease - genetics Alzheimer's disease Apolipoprotein E Apolipoproteins E - genetics Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Gene Frequency Genetic Predisposition to Disease Genotype Homozygote Humans Male Medical sciences Middle Aged Neurology Odds Ratio Polymorphism, Genetic - physiology Polymorphisms Promoter Regions, Genetic - genetics Reference Values |
| title | The −491 TT apolipoprotein E promoter polymorphism is associated with reduced risk for sporadic Alzheimer's disease |
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