Histological remodeling in an ovine heart failure model resembles human ischemic cardiomyopathy

Staged coronary embolization, causing myocardial microinfarctions, has been shown in dogs and sheep to cause chronic ischemic heart failure (HF) that resembles the hemodynamics of the human condition. However, its histopathological basis remains unclear. We examined the hypothesis that the ventricul...

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Bibliographic Details
Published in:Cardiovascular pathology 2001-01, Vol.10 (1), p.19-27
Main Authors: Ikeda, Yoshihiko, Yutani, Chikao, Huang, Yifei, Masuda, Kazuyoshi, Yuasa, Takeshi, Kawaguchi, Osamu, Hunyor, Stephen N
Format: Article
Language:English
Subjects:
Animals
Body Weight
Chronic heart failure model
Disease Models, Animal
Echocardiography
Fibrosis - pathology
Heart Failure - etiology
Heart Failure - pathology
Heart Failure - physiopathology
Heart Ventricles - pathology
Histopathology
Humans
Ischemic cardiomyopahy
Microspheres
Myocardial Ischemia - pathology
Myocardial Ischemia - physiopathology
Myocardium - pathology
Organ Size
Sheep
Species Specificity
Ventricular Dysfunction, Left - physiopathology
Ventricular Remodeling
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Summary:Staged coronary embolization, causing myocardial microinfarctions, has been shown in dogs and sheep to cause chronic ischemic heart failure (HF) that resembles the hemodynamics of the human condition. However, its histopathological basis remains unclear. We examined the hypothesis that the ventricular remodeling seen in such sheep resembles the histopathology of human ischemic cardiomyopathy (ICM). Understanding the pathophysiology of this model will determine its place in the development of treatment strategies for HF. Global left ventricular (LV) damage resulting in HF was induced by staged coronary embolization in 11 sheep. Six others served as controls (normal control, NC). In HF sheep, the heart was harvested 6 months after LV ejection fraction (EF) had stabilized at
ISSN:1054-8807
1879-1336
DOI:10.1016/S1054-8807(00)00060-0