Chemokines and allergic disease

Understanding the chemokine network has become one of the great challenges for researchers interested in inflammatory mechanisms and inflammation-based diseases. The complexity and diversity of the system provide not only a daunting task for its comprehension but also numerous opportunities for deve...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 1999-10, Vol.104 (4), p.723-742
Main Authors: Nickel, Renate, Beck, Lisa A., Stellato, Cristiana, Schleimer, Robert P.
Format: Article
Language:English
Subjects:
Allergic disease
Allergic diseases
angiogenesis
Biological and medical sciences
chemokine
Chemokines - antagonists & inhibitors
Chemokines - classification
Chemokines - genetics
Chemokines - metabolism
chemotaxis
Chemotaxis, Leukocyte
Chromosome Mapping
Continental Population Groups
cytokines
Endothelium, Vascular
eosinophil
General aspects
glucocorticoids
hematopoieses
Hematopoiesis
Humans
Hypersensitivity - epidemiology
Hypersensitivity - immunology
Immunopathology
mediators
Medical sciences
Models, Immunological
Neovascularization, Physiologic
Receptors, Chemokine - antagonists & inhibitors
Receptors, Chemokine - classification
Receptors, Chemokine - genetics
Receptors, Chemokine - metabolism
transendothelial migration
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Summary:Understanding the chemokine network has become one of the great challenges for researchers interested in inflammatory mechanisms and inflammation-based diseases. The complexity and diversity of the system provide not only a daunting task for its comprehension but also numerous opportunities for development of new, targeted therapies. It is now certain that chemokines are involved as important mediators of allergic inflammation; the fine details and scope of their roles are now under investigation. Presumably, because of distinct pressures on the immune systems of people living in different geographic regions, genetic variation of ligands, receptors, and regulatory regions in the network have emerged. Establishing the roles of these polymorphisms in determining disease susceptibility or progression among individuals and in distinct ethnic groups will provide a basis for improved understanding and treatment of allergic diseases. (J Allergy Clin Immunol 1999;104:723-42.)
ISSN:0091-6749
1097-6825
DOI:10.1016/S0091-6749(99)70281-2