Sodium-calcium exchanger is initially expressed in a heart-restricted pattern within the early mouse embryo

Although the sodium-calcium exchanger (NCX1) is encoded by a single gene, it is widely expressed in both fetal and adult tissues and functions in many diverse physiological processes to maintain intracellular calcium homeostasis. In order to determine whether NCX1 is also ubiquitously expressed in t...

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Bibliographic Details
Published in:Mechanisms of development 1999-10, Vol.88 (1), p.119-122
Main Authors: Koushik, Srinagesh V., Bundy, Justin, Conway, Simon J.
Format: Article
Language:English
Subjects:
Animals
Cardiac crescent
Embryo
Gene Expression Regulation, Developmental
Heart - embryology
Heart - physiology
Heart-restricted expression
Heartbeat
Mice
Mouse
Reverse Transcriptase Polymerase Chain Reaction
Sodium-calcium exchanger
Sodium-Calcium Exchanger - genetics
Sodium-Calcium Exchanger - metabolism
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Summary:Although the sodium-calcium exchanger (NCX1) is encoded by a single gene, it is widely expressed in both fetal and adult tissues and functions in many diverse physiological processes to maintain intracellular calcium homeostasis. In order to determine whether NCX1 is also ubiquitously expressed in the early mouse embryo, in situ hybridization and RT-PCR were used to determine the spacio-temporal expression of NCX1. Our results indicate that NCX1 expression is present within the 7.75–8.0 dpc cardiogenic plate before the first heartbeat, and that NCX1 is initially expressed in a heart-restricted pattern within the early mouse embryo. However, in more developed embryos (11.0 dpc and older) NCX1 is expressed in other tissues.
ISSN:0925-4773
1872-6356
DOI:10.1016/S0925-4773(99)00177-X