Long-term recovery of left ventricular function after primary angioplasty for acute myocardial infarction

Aims To investigate changes in left ventricular function in the first 6 months after acute myocardial infarction treated with primary angioplasty. To assess clinical variables, associated with recovery of left ventricular function after acute myocardial infarction. Methods Changes in left ventricula...

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Published in:European heart journal 2001-05, Vol.22 (9), p.785-790
Main Authors: Ottervanger, J.P, Van't Hof, A.W.J, Reiffers, S, Hoorntje, J.C.A, Suryapranata, H, de Boer, M.J, Zijlstra, F
Format: Article
Language:English
Subjects:
Acute myocardial infarction
Angioplasty
Biological and medical sciences
Cardiology. Vascular system
Coronary heart disease
Female
Heart
Humans
left ventricular ejection fraction
Linear Models
Male
Medical sciences
Middle Aged
Multivariate Analysis
Myocardial Infarction - physiopathology
Myocardial Infarction - surgery
primary angioplasty
Prognosis
Prospective Studies
Stroke Volume
stunning
Ventricular Function, Left - physiology
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container_end_page 790
container_issue 9
container_start_page 785
container_title European heart journal
container_volume 22
creator Ottervanger, J.P
Van't Hof, A.W.J
Reiffers, S
Hoorntje, J.C.A
Suryapranata, H
de Boer, M.J
Zijlstra, F
description Aims To investigate changes in left ventricular function in the first 6 months after acute myocardial infarction treated with primary angioplasty. To assess clinical variables, associated with recovery of left ventricular function after acute myocardial infarction. Methods Changes in left ventricular function were studied in 600 consecutive patients with acute myocardial infarction, all treated with primary angioplasty. Left ventricular ejection fraction was measured by radionuclide ventriculography in survivors at day 4 and after 6 months. Patients with a recurrent myocardial infarction within the 6 months were excluded. Results Successful reperfusion (TIMI 3 flow) by primary angioplasty was achieved in 89% of patients. The mean ejection fraction at discharge was 43·7%±11·4, whereas the mean ejection fraction after 6 months was 46·3%±11·5 (P
doi_str_mv 10.1053/euhj.2000.2316
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To assess clinical variables, associated with recovery of left ventricular function after acute myocardial infarction. Methods Changes in left ventricular function were studied in 600 consecutive patients with acute myocardial infarction, all treated with primary angioplasty. Left ventricular ejection fraction was measured by radionuclide ventriculography in survivors at day 4 and after 6 months. Patients with a recurrent myocardial infarction within the 6 months were excluded. Results Successful reperfusion (TIMI 3 flow) by primary angioplasty was achieved in 89% of patients. The mean ejection fraction at discharge was 43·7%±11·4, whereas the mean ejection fraction after 6 months was 46·3%±11·5 (P&lt;0·01). During the 6 months, the mean relative improvement in left ventricular ejection fraction was 6%. An improvement in left ventricular function was observed in 48% of the patients; 25% of the patients had a decrease, whereas in the remaining patients there was no change. After univariate and multivariate analysis, an anterior infarction location, an ejection fraction at discharge ≤40% and single-vessel disease were significant predictors of left ventricular improvement during the 6 months. Conclusions After acute myocardial infarction treated with primary angioplasty there was a significant recovery of left ventricular function during the first 6 months after the infarction. An anterior myocardial infarction, single-vessel coronary artery disease, and an initially depressed left ventricular function were independently associated with recovery of left ventricular function. Multivessel disease was associated with absence of functional recovery. Additional studies, investigating complete revascularization are needed, as this approach may potentially improve long-term left ventricular function.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1053/euhj.2000.2316</identifier><identifier>PMID: 11350111</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Acute myocardial infarction ; Angioplasty ; Biological and medical sciences ; Cardiology. Vascular system ; Coronary heart disease ; Female ; Heart ; Humans ; left ventricular ejection fraction ; Linear Models ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Myocardial Infarction - physiopathology ; Myocardial Infarction - surgery ; primary angioplasty ; Prognosis ; Prospective Studies ; Stroke Volume ; stunning ; Ventricular Function, Left - physiology</subject><ispartof>European heart journal, 2001-05, Vol.22 (9), p.785-790</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright 2001 The European Society of Cardiology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-79539d898584424bdc049cf6e11f424e5377a779880f64496a5f8e99538c08383</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=983444$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11350111$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ottervanger, J.P</creatorcontrib><creatorcontrib>Van't Hof, A.W.J</creatorcontrib><creatorcontrib>Reiffers, S</creatorcontrib><creatorcontrib>Hoorntje, J.C.A</creatorcontrib><creatorcontrib>Suryapranata, H</creatorcontrib><creatorcontrib>de Boer, M.J</creatorcontrib><creatorcontrib>Zijlstra, F</creatorcontrib><title>Long-term recovery of left ventricular function after primary angioplasty for acute myocardial infarction</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description>Aims To investigate changes in left ventricular function in the first 6 months after acute myocardial infarction treated with primary angioplasty. To assess clinical variables, associated with recovery of left ventricular function after acute myocardial infarction. Methods Changes in left ventricular function were studied in 600 consecutive patients with acute myocardial infarction, all treated with primary angioplasty. Left ventricular ejection fraction was measured by radionuclide ventriculography in survivors at day 4 and after 6 months. Patients with a recurrent myocardial infarction within the 6 months were excluded. Results Successful reperfusion (TIMI 3 flow) by primary angioplasty was achieved in 89% of patients. The mean ejection fraction at discharge was 43·7%±11·4, whereas the mean ejection fraction after 6 months was 46·3%±11·5 (P&lt;0·01). During the 6 months, the mean relative improvement in left ventricular ejection fraction was 6%. An improvement in left ventricular function was observed in 48% of the patients; 25% of the patients had a decrease, whereas in the remaining patients there was no change. After univariate and multivariate analysis, an anterior infarction location, an ejection fraction at discharge ≤40% and single-vessel disease were significant predictors of left ventricular improvement during the 6 months. Conclusions After acute myocardial infarction treated with primary angioplasty there was a significant recovery of left ventricular function during the first 6 months after the infarction. An anterior myocardial infarction, single-vessel coronary artery disease, and an initially depressed left ventricular function were independently associated with recovery of left ventricular function. Multivessel disease was associated with absence of functional recovery. Additional studies, investigating complete revascularization are needed, as this approach may potentially improve long-term left ventricular function.</description><subject>Acute myocardial infarction</subject><subject>Angioplasty</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Coronary heart disease</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>left ventricular ejection fraction</subject><subject>Linear Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Myocardial Infarction - surgery</subject><subject>primary angioplasty</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Stroke Volume</subject><subject>stunning</subject><subject>Ventricular Function, Left - physiology</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNpF0M1LHDEYBvBQWupqvfYogUJvs00m30dZqyss6EGpeAkxm9jozGRNMtL975t1Bz2Fl_yeF94HgO8YzTFi5Jcb_z7NW4TQvCWYfwIzzNq2UZyyz2CGsGIN5_LuABzm_FSV5Jh_BQcYE4YwxjMQVnF4bIpLPUzOxleXtjB62Dlf4KsbSgp27EyCfhxsCXGAxlcMNyn0plIzPIa46UwuW-hjgsaOxcF-G61J62A6GAZv0lvyG_jiTZfd8fQegdvz3zeLZbO6urhcnK4aSzkpjVCMqLVUkklKW_qwtogq67nD2NfZMSKEEUJJiTynVHHDvHSqpqRFkkhyBH7u925SfBldLroP2bquM4OLY9aiKqwEqXC-hzbFnJPzerpKY6R35epduXpXrt6VWwMn0-bxoXfrDz61WcGPCZhsTeeTGWzI705JQimtqtmrkIv79_5r0rPmggiml3f3-s_NanF9dr7QS_IfUKiSWg</recordid><startdate>20010501</startdate><enddate>20010501</enddate><creator>Ottervanger, J.P</creator><creator>Van't Hof, A.W.J</creator><creator>Reiffers, S</creator><creator>Hoorntje, J.C.A</creator><creator>Suryapranata, H</creator><creator>de Boer, M.J</creator><creator>Zijlstra, F</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010501</creationdate><title>Long-term recovery of left ventricular function after primary angioplasty for acute myocardial infarction</title><author>Ottervanger, J.P ; Van't Hof, A.W.J ; Reiffers, S ; Hoorntje, J.C.A ; Suryapranata, H ; de Boer, M.J ; Zijlstra, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-79539d898584424bdc049cf6e11f424e5377a779880f64496a5f8e99538c08383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Acute myocardial infarction</topic><topic>Angioplasty</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Coronary heart disease</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>left ventricular ejection fraction</topic><topic>Linear Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Myocardial Infarction - surgery</topic><topic>primary angioplasty</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Stroke Volume</topic><topic>stunning</topic><topic>Ventricular Function, Left - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ottervanger, J.P</creatorcontrib><creatorcontrib>Van't Hof, A.W.J</creatorcontrib><creatorcontrib>Reiffers, S</creatorcontrib><creatorcontrib>Hoorntje, J.C.A</creatorcontrib><creatorcontrib>Suryapranata, H</creatorcontrib><creatorcontrib>de Boer, M.J</creatorcontrib><creatorcontrib>Zijlstra, F</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ottervanger, J.P</au><au>Van't Hof, A.W.J</au><au>Reiffers, S</au><au>Hoorntje, J.C.A</au><au>Suryapranata, H</au><au>de Boer, M.J</au><au>Zijlstra, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term recovery of left ventricular function after primary angioplasty for acute myocardial infarction</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>2001-05-01</date><risdate>2001</risdate><volume>22</volume><issue>9</issue><spage>785</spage><epage>790</epage><pages>785-790</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Aims To investigate changes in left ventricular function in the first 6 months after acute myocardial infarction treated with primary angioplasty. To assess clinical variables, associated with recovery of left ventricular function after acute myocardial infarction. Methods Changes in left ventricular function were studied in 600 consecutive patients with acute myocardial infarction, all treated with primary angioplasty. Left ventricular ejection fraction was measured by radionuclide ventriculography in survivors at day 4 and after 6 months. Patients with a recurrent myocardial infarction within the 6 months were excluded. Results Successful reperfusion (TIMI 3 flow) by primary angioplasty was achieved in 89% of patients. The mean ejection fraction at discharge was 43·7%±11·4, whereas the mean ejection fraction after 6 months was 46·3%±11·5 (P&lt;0·01). During the 6 months, the mean relative improvement in left ventricular ejection fraction was 6%. An improvement in left ventricular function was observed in 48% of the patients; 25% of the patients had a decrease, whereas in the remaining patients there was no change. After univariate and multivariate analysis, an anterior infarction location, an ejection fraction at discharge ≤40% and single-vessel disease were significant predictors of left ventricular improvement during the 6 months. Conclusions After acute myocardial infarction treated with primary angioplasty there was a significant recovery of left ventricular function during the first 6 months after the infarction. An anterior myocardial infarction, single-vessel coronary artery disease, and an initially depressed left ventricular function were independently associated with recovery of left ventricular function. Multivessel disease was associated with absence of functional recovery. Additional studies, investigating complete revascularization are needed, as this approach may potentially improve long-term left ventricular function.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>11350111</pmid><doi>10.1053/euhj.2000.2316</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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source Oxford Journals Online
subjects Acute myocardial infarction
Angioplasty
Biological and medical sciences
Cardiology. Vascular system
Coronary heart disease
Female
Heart
Humans
left ventricular ejection fraction
Linear Models
Male
Medical sciences
Middle Aged
Multivariate Analysis
Myocardial Infarction - physiopathology
Myocardial Infarction - surgery
primary angioplasty
Prognosis
Prospective Studies
Stroke Volume
stunning
Ventricular Function, Left - physiology
title Long-term recovery of left ventricular function after primary angioplasty for acute myocardial infarction
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