Dermal and transdermal delivery of protein pharmaceuticals: lipid-based delivery systems for interferon α

The dermal and transdermal delivery of protein pharmaceuticals faces enormous challenges, and at the same time has very significant potential for the non‐invasive treatment of both localized and systemic diseases. In this article we review the various approaches used to enhance and control the deliv...

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Bibliographic Details
Published in:Biotechnology and applied biochemistry 1999-10, Vol.30 (2), p.129-137
Main Authors: Foldvari, Marianna, Baca-Estrada, Maria E., He, Zhihong, Hu, Jiaping, Attah-Poku, Samuel, King, Martin
Format: Article
Language:English
Subjects:
a-Interferon
Acetylation
Administration, Cutaneous
Administration, Topical
Biological and medical sciences
Biotechnology
Drug Carriers
Drug Delivery Systems
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
Humans
Industrial applications and implications. Economical aspects
Interferon-alpha - administration & dosage
Interferon-alpha - chemistry
Interferon-alpha - pharmacokinetics
Liposomes
Miscellaneous
Skin Absorption
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Summary:The dermal and transdermal delivery of protein pharmaceuticals faces enormous challenges, and at the same time has very significant potential for the non‐invasive treatment of both localized and systemic diseases. In this article we review the various approaches used to enhance and control the delivery of protein therapeutic agents through the dermal barrier. We show results of the delivery of interferon (IFN) α, an antiviral agent used in the treatment of condylomata acuminata (genital warts), using lipid‐based delivery systems (LBDS). In the general category of LBDS, we investigated the use of liposomes and fatty acylation as ways to increase IFNα delivery into human skin.
ISSN:0885-4513
1470-8744
DOI:10.1111/j.1470-8744.1999.tb00903.x