New insight into calcinosis of juvenile dermatomyositis: A study of composition and treatment

Milk of calcium developed in 2 children with juvenile dermatomyositis. The fluid of the collection contained macrophages, interleukin-6, IL-1, and tumor necrosis factor. The patient who had dystrophic calcinosis had a dramatic improvement with the introduction of alendronate. These findings suggest...

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Bibliographic Details
Published in:The Journal of pediatrics 2001-05, Vol.138 (5), p.763-766
Main Authors: Mukamel, Masza, Horev, Gadi, Mimouni, Marc
Format: Article
Language:English
Subjects:
Adolescent
Alendronate - therapeutic use
Biological and medical sciences
Calcinosis - drug therapy
Calcinosis - etiology
Calcinosis - metabolism
Dermatomyositis - complications
Humans
Interleukin-1 - analysis
Macrophages
Male
Medical sciences
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Treatment Outcome
Tropical medicine
Tumor Necrosis Factor-alpha - analysis
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Description
Summary:Milk of calcium developed in 2 children with juvenile dermatomyositis. The fluid of the collection contained macrophages, interleukin-6, IL-1, and tumor necrosis factor. The patient who had dystrophic calcinosis had a dramatic improvement with the introduction of alendronate. These findings suggest that calcinosis of juvenile dermatomyositis may be mediated by activated macrophages and that alendronate can be an effective treatment for this condition. (J Pediatr 2001;138:763-6)
ISSN:0022-3476
1097-6833
DOI:10.1067/mpd.2001.112473