Prevention of postoperative nausea and vomiting in gynaecological laparotomies : A comparison of tropisetron and ondansetron

In a randomized, double-blind study, the antiemetic efficacy of a single bolus of tropisetron 5 mg (group T, 37 patients), ondansetron 4 mg (group O, 39 patients) or saline (group C, 45 patients) given at induction was compared in a homogeneous group of 121 patients undergoing gynaecological laparot...

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Published in:Anaesthesia and intensive care 1999-10, Vol.27 (5), p.471-476
Main Authors: TSUI, S. L, NG, K. F. J, WONG, L. C, TANG, G. W. K, PUN, T. C, YANG, J. C. S
Format: Article
Language:English
Subjects:
Antiemetics - therapeutic use
Biological and medical sciences
Digestive system
Double-Blind Method
Female
Gynecologic Surgical Procedures
Humans
Indoles - therapeutic use
Laparotomy
Medical sciences
Middle Aged
Ondansetron - therapeutic use
Pharmacology. Drug treatments
Postoperative Nausea and Vomiting - prevention & control
Serotonin Antagonists - therapeutic use
Tropisetron
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cited_by cdi_FETCH-LOGICAL-c397t-339c7aabfed4e8d02f3e7ad89b8343887b3fc35ab8b7c8ba8c4bd17ce66456f23
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container_title Anaesthesia and intensive care
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creator TSUI, S. L
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description In a randomized, double-blind study, the antiemetic efficacy of a single bolus of tropisetron 5 mg (group T, 37 patients), ondansetron 4 mg (group O, 39 patients) or saline (group C, 45 patients) given at induction was compared in a homogeneous group of 121 patients undergoing gynaecological laparotomy and receiving postoperative patient-controlled intravenous morphine for 24 to 48 hours. Fewer group T and group O patients developed severe nausea compared to group C (P < 0.01, log rank test in Kaplan-Meier analysis). Group T patients also had lower nausea scores than group O at 8 to 16h (P < 0.05). The overall incidences of severe nausea in groups T, O, and C were 5.4%, 17.9%, and 44.4% respectively (P < 0.001, group T vs group C; P < 0.05 group O vs group C). In conclusion, the 5-hydroxytryptamine 3 receptor antagonists tropisetron and ondansetron were superior to placebo in preventing PONV.
doi_str_mv 10.1177/0310057x9902700506
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source Sage Journals Online; Alma/SFX Local Collection
subjects Antiemetics - therapeutic use
Biological and medical sciences
Digestive system
Double-Blind Method
Female
Gynecologic Surgical Procedures
Humans
Indoles - therapeutic use
Laparotomy
Medical sciences
Middle Aged
Ondansetron - therapeutic use
Pharmacology. Drug treatments
Postoperative Nausea and Vomiting - prevention & control
Serotonin Antagonists - therapeutic use
Tropisetron
title Prevention of postoperative nausea and vomiting in gynaecological laparotomies : A comparison of tropisetron and ondansetron
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