Synchrony of rest tremor in multiple limbs in Parkinson's disease : evidence for multiple oscillators

Recent evidence points to involvement of central nervous system oscillators in Parkinson's disease (PD) rest tremor. It remains unknown whether one or multiple oscillators cause tremor in multiple limbs. Based on the prediction that multiple oscillators would cause low coherence even with simil...

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Bibliographic Details
Published in:Journal of Neural Transmission 2001-01, Vol.108 (3), p.287-296
Main Authors: BEN-PAZI, H, BERGMAN, H, GOLDBERG, J. A, GILADI, N, HANSEL, D, RECHES, A, SIMON, E. S
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
Biological Clocks - physiology
Brain - pathology
Brain - physiopathology
Chin - innervation
Chin - physiopathology
Cortical Synchronization
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Extremities - innervation
Extremities - physiopathology
Female
Functional Laterality - physiology
Humans
Male
Medical sciences
Middle Aged
Neural Pathways - pathology
Neural Pathways - physiopathology
Neurology
Parkinson Disease - pathology
Parkinson Disease - physiopathology
tremor
Tremor - pathology
Tremor - physiopathology
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Summary:Recent evidence points to involvement of central nervous system oscillators in Parkinson's disease (PD) rest tremor. It remains unknown whether one or multiple oscillators cause tremor in multiple limbs. Based on the prediction that multiple oscillators would cause low coherence even with similar average frequency, we studied 22 PD patients using accelerometers on multiple limbs. Records were digitized and spectral analysis was performed. Peak frequencies in the arms, legs, and chin were similar, indicating that biomechanical factors did not determine the frequency. Coherence between different axes of individual accelerometers and between different segments of the same limb was high. However, coherence between tremor in different limbs was low. There was no consistent pattern across patients of ipsi- vs. contralateral predominance of coherence. These data suggest that tremor in PD is generated by multiple oscillatory circuits, which operate on similar frequencies.
ISSN:0300-9564
1435-1463
DOI:10.1007/s007020170074