Effect of sex hormones on cardiac mass

Increased left-ventricular mass is an important cardiovascular risk factor for morbidity and mortality. Apart from obvious differences in cardiac size, the changes in left-ventricular mass in response to age and hypertrophic stimuli are very different in men and women. Whereas left-ventricular mass...

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Bibliographic Details
Published in:The Lancet (British edition) 2001-04, Vol.357 (9265), p.1354-1356
Main Authors: Hayward, Christopher S, Webb, Carolyn M, Collins, Peter
Format: Article
Language:English
Subjects:
Age
Age Factors
Androgens
Animals
Aortic stenosis
Biological and medical sciences
Cardiomyocytes
Cardiovascular disease
Cardiovascular diseases
Esophagus
Estrogens
Estrogens - pharmacology
Estrogens - physiology
Eutrophication
Females
Gastroenterology. Liver. Pancreas. Abdomen
Gender differences
Gene expression
Gonadal Steroid Hormones - pharmacology
Gonadal Steroid Hormones - physiology
Health risk assessment
Health risks
Heart
Hormone replacement therapy
Hormones
Humans
Hypertension
Hypertrophy, Left Ventricular - physiopathology
Hypotheses
Medical sciences
Men
Morbidity
Mortality
Multivariate analysis
Osteoporosis
Protein synthesis
Puberty
Risk factors
Sex
Sex Factors
Sex hormones
Sexes
Stenosis
Swimming
Testosterone
Testosterone - pharmacology
Testosterone - physiology
Tumors
Ventricle
Womens health
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Summary:Increased left-ventricular mass is an important cardiovascular risk factor for morbidity and mortality. Apart from obvious differences in cardiac size, the changes in left-ventricular mass in response to age and hypertrophic stimuli are very different in men and women. Whereas left-ventricular mass increases with age in apparently healthy women, it remains constant in men. Under increased cardiac loading conditions, such as hypertension or aortic stenosis, this disparity between sexes is even more striking. Findings are especially pronounced in people aged 50 years or older, in whom reproductive hormone concentrations have fallen. Whether the differences in left-ventricular mass changes are related to endogenous sex-hormone concentrations has never been shown. Androgens have anabolic effects on cardiac cells, and oestrogens have antiproliferative properties, we therefore postulate that the normal decline in endogenous sex hormones with age has contrary effects on ventricular mass in men and women in normal and pathological states.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(00)04523-2