Tissue Distribution of the Human Soluble Guanylate Cyclases

Soluble guanylate cyclase (sGC) is an important component of the NO signaling pathway. Human sGC isoforms α1, α2, and β1 show differential mRNA tissue distributions. α1 and β1 are expressed in most tissues; however, the α2 isoform shows a more restricted expression pattern with high levels in brain,...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 1999-10, Vol.263 (3), p.696-701
Main Authors: Budworth, Joanna, Meillerais, Sylvie, Charles, Ian, Powell, Ken
Format: Article
Language:English
Subjects:
Blotting, Northern
Brain - enzymology
Cytoplasm - enzymology
Female
Gene Expression Regulation, Enzymologic
Guanylate Cyclase - analysis
Guanylate Cyclase - genetics
Humans
Isoenzymes - analysis
Isoenzymes - genetics
Male
Organ Specificity
Placenta - enzymology
Pregnancy
RNA, Messenger - genetics
Spleen - enzymology
Transcription, Genetic
Uterus - enzymology
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Summary:Soluble guanylate cyclase (sGC) is an important component of the NO signaling pathway. Human sGC isoforms α1, α2, and β1 show differential mRNA tissue distributions. α1 and β1 are expressed in most tissues; however, the α2 isoform shows a more restricted expression pattern with high levels in brain, placenta, spleen, and uterus only. Both α subunits exist as multiple transcripts whereas β1 exists as a single message. This study reports for the first time the tissue distribution of human sGC message and demonstrates that sGC isoforms are nonuniformly expressed which may be useful if the enzyme is to be exploited as a therapeutic target.
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.1999.1444