A study of anti-carbonic anhydrase II antibodies in rheumatic autoimmune diseases

Autoantibodies to human carbonic anhydrase II (CAII) were screened by ELISA in 109 sera from Asian–Japanese patients with systemic lupus erythematosus (SLE), primary Sjögren’s syndrome (Sjs), progressive systemic sclerosis (PSS) and dermatomyositis (DM). Anti-CAII antibodies were positive in 24.1% o...

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Bibliographic Details
Published in:Journal of dermatological science 1999-11, Vol.21 (3), p.183-186
Main Authors: Ono, Mariko, Ono, Masashi, Watanabe, Keisuke, Miyashita, Yuko, Inagaki, Yasunori, Ueki, Hiroaki
Format: Article
Language:English
Subjects:
Antibody Specificity
Autoantibodies - immunology
Autoantibody
Autoimmune Diseases - immunology
Carbonic anhydrase II
Carbonic Anhydrases - immunology
Enzyme-Linked Immunosorbent Assay
Humans
Rheumatic autoimmune disease
Rheumatic Diseases - immunology
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Summary:Autoantibodies to human carbonic anhydrase II (CAII) were screened by ELISA in 109 sera from Asian–Japanese patients with systemic lupus erythematosus (SLE), primary Sjögren’s syndrome (Sjs), progressive systemic sclerosis (PSS) and dermatomyositis (DM). Anti-CAII antibodies were positive in 24.1% of SLE, 20.0% of primary Sjs, 16.7% of PSS and 25.0% of DM. On the other hand, sera from atopic dermatitis, bullous pemphigoid and psoriasis patients showed no activity for anti-CAII antibodies. CAII could be a common exonuclear autoantigen in subsets of rheumatic autoimmune diseases.
ISSN:0923-1811
1873-569X
DOI:10.1016/S0923-1811(99)00032-8