Chromosome 18 deletions are common events in classical midgut carcinoid tumors

Classical midgut carcinoids are rare intestinal neuroendocrine tumors that often present with metastases at diagnosis. In contrast to foregut carcinoids, midgut carcinoids are not related to the multiple endocrine neoplasia type 1 syndrome, and the mechanisms involved in their tumorigenesis are unkn...

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Bibliographic Details
Published in:International journal of cancer 2001-06, Vol.92 (6), p.812-815
Main Authors: Löllgen, Ruth‐Mari, Hessman, Ola, Szabo, Eva, Westin, Gunnar, Åkerström, Göran
Format: Article
Language:English
Subjects:
Adult
Aged
Alleles
Biological and medical sciences
carcinoid tumor
Carcinoid Tumor - genetics
Chromosome 18
Chromosome Deletion
Chromosomes, Human, Pair 18
DCC gene
DNA-Binding Proteins - genetics
DPC4 gene
Gastroenterology. Liver. Pancreas. Abdomen
Gene Deletion
Homozygote
Humans
Immunohistochemistry
Intestinal Neoplasms - genetics
Loss of Heterozygosity
Medical sciences
Microsatellite Repeats
Middle Aged
midgut
Mutation
Pancreatic Neoplasms - genetics
Smad4 gene
Smad4 Protein
Smad4/DPC4
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Trans-Activators - genetics
Tumors
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Summary:Classical midgut carcinoids are rare intestinal neuroendocrine tumors that often present with metastases at diagnosis. In contrast to foregut carcinoids, midgut carcinoids are not related to the multiple endocrine neoplasia type 1 syndrome, and the mechanisms involved in their tumorigenesis are unknown. Eight classical midgut carcinoids were analyzed by genome‐wide screening for loss of heterozygosity. Deletions on chromosome 18 were found in 88% of the tumors. DNA sequencing and immunohistochemical staining for Smad4/DPC4, which often is homozygously mutated in pancreatic and colon carcinomas, revealed no aberrations. In 1 tumor, a region telomeric to the Smad4/DPC4/DCC genes at 18q21 was deleted. Other chromosomes were affected in 3 lesions only. The high frequency of chromosome 18 deletions strongly indicates a genetic alteration of importance in classical midgut carcinoid tumorigenesis, apparently not involving the Smad4/DPC4 gene. © 2001 Wiley‐Liss, Inc.
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.1276