Cerebrovascular disease and depression symptoms in the Cardiovascular Health Study

Evidence is mounting linking cerebrovascular disease with depressive symptoms in the elderly. Lesions in both white and gray matter have been associated with depressive symptoms and major depression. We sought to investigate the relationship between depressive symptoms and white and gray matter lesi...

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Bibliographic Details
Published in:Stroke (1970) 1999-10, Vol.30 (10), p.2159-2166
Main Authors: STEFFENS, D. C, HELMS, M. J, RANGA RAMA KRISHNAN, K, BURKE, G. L
Format: Article
Language:English
Subjects:
Activities of Daily Living
Aged
Biological and medical sciences
Brain - pathology
Cardiovascular Diseases - complications
Cardiovascular Diseases - psychology
Cerebrovascular Disorders - complications
Cerebrovascular Disorders - diagnosis
Cerebrovascular Disorders - psychology
Cross-Sectional Studies
Depression - complications
Depression - diagnosis
Female
Humans
Logistic Models
Magnetic Resonance Imaging
Male
Medical sciences
Neurology
Neuropsychological Tests
Risk Factors
Vascular diseases and vascular malformations of the nervous system
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Summary:Evidence is mounting linking cerebrovascular disease with depressive symptoms in the elderly. Lesions in both white and gray matter have been associated with depressive symptoms and major depression. We sought to investigate the relationship between depressive symptoms and white and gray matter lesions in subjects participating in the Cardiovascular Health Study. In a sample of 3660 men and women who underwent a standardized interview, physical examination, and MRI scan, we examined the association between number of white and gray matter lesions and white matter grade (a measure of severity) and reported depressive symptoms using a modified version of the Centers for Epidemiologic Studies Depression (CES-D) scale. We controlled for a variety of demographic and medical variables as well as functional status and Modified Mini-Mental State Examination score. The number of small (
ISSN:0039-2499
1524-4628
DOI:10.1161/01.str.30.10.2159