Carriage of Multidrug-Resistant Streptococcus pneumoniae and Impact of Chemoprophylaxis During an Outbreak of Meningitis at a Day Care Center

• Published in: Clinical infectious diseases 1999-11, Vol.29 (5), p.1257-1264
• Main Authors: Craig, Allen S., Erwin, Paul C., Schaffner, William, Elliott, John A., Moore, William L., Ussery, Xilla T., Patterson, Lori, Dake, Anthony D., Hannah, Stuart G., Butler, Jay C.
• Format: Article
• Language: English
• Subjects: Antibiotics; Bacterial Vaccines - immunology; Carrier State - drug therapy; Chemoprevention; Child; Child Day Care Centers; Child, Preschool; Children; Clinical Articles; Day care centers; Disease Outbreaks; Drug Resistance, Microbial; Drug Resistance, Multiple; Epidemiology; Female; Humans; Infant; Male; Meningitis, Pneumococcal - epidemiology; Meningitis, Pneumococcal - prevention & control; Nasopharynx - microbiology; Patient Compliance; Pediatrics; Pneumococcal meningitis; Pneumococcal Vaccines; Preventive medicine; Streptococcus pneumoniae; Streptococcus pneumoniae - drug effects
• ISSN: 1058-4838; 1537-6591
• DOI: 10.1086/313451

Three cases of meningitis due to multidrug-resistant serotype 14 Streptococcus pneumoniae occurred at a day care center (DCC) over 5 days. Cultures of nasopharyngeal samples were done at the index DCC, 2 comparison DCCs, and a pediatrics practice. Isolates were serotyped and subtyped by pulsed-field gel electrophoresis (PFGE) with SmaI. Pneumococcal carriage rates ranged from 44%–65% atthe 3 DCCs and 29% in the pediatrics practice. Carriage of multidrug-resistant serotype 14 S. pneumoniae was noted in 13%–19% of children at the 3 DCCs. An outbreak strain was identified by PFGE at the index DCC and 1 other DCC; a closely related strain was found in the third DCC. Carriage of the outbreak strain was associated with being age 0–24 months, antibiotic use, upper respiratory tract infections, and otitis media. DCC contacts of the ill children were offered chemoprophylaxis with rifampin and clindamycin, which produced a profound but transient decrease in carriage. No additional cases occurred.