Bacteremic Pneumonia Due to Staphylococcus aureus: A Comparison of Disease Caused by Methicillin-Resistant and Methicillin-Susceptible Organisms

We performed a prospective study of all patients with bacteremic pneumonia due to Staphylococcus aureus over a period of 6 years during an outbreak of methicillin-resistant S. aureus (MRSA). Patients with bacteremic pneumonia due to MRSA (32 cases) or methicillin-susceptible S. aureus (MSSA; 54 case...

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Bibliographic Details
Published in:Clinical infectious diseases 1999-11, Vol.29 (5), p.1171-1177
Main Authors: González, Carmen, Rubio, Margarita, Romero-Vivas, José, González, Miguel, Picazo, Juan J.
Format: Article
Language:English
Subjects:
Adult
Aged
Antibiotics
Aspiration pneumonia
Bacteremia - drug therapy
Bacterial diseases
Bacterial diseases of the respiratory system
Bacterial pneumonia
Biological and medical sciences
Clinical Articles
Epidemiology
Female
Human bacterial diseases
Humans
Infections
Infectious diseases
Lung diseases
Male
Medical sciences
Methicillin - pharmacology
Methicillin Resistance
Middle Aged
Mortality
Penicillins - pharmacology
Pneumonia
Pneumonia, Staphylococcal - drug therapy
Prospective Studies
Staphylococcal Infections - drug therapy
Staphylococcal pneumonia
Staphylococcus aureus
Staphylococcus aureus - drug effects
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Summary:We performed a prospective study of all patients with bacteremic pneumonia due to Staphylococcus aureus over a period of 6 years during an outbreak of methicillin-resistant S. aureus (MRSA). Patients with bacteremic pneumonia due to MRSA (32 cases) or methicillin-susceptible S. aureus (MSSA; 54 cases) were compared. The patients with MRSA pneumonia were older and were more likely than those with MSSA pneumonia to have predisposing factors for acquisition of the infection. There were no differences in clinical findings, radiological pattern, or complications in clinical evolution among patients with MRSA and MSSA pneumonia. Mortality was significantly higher among MSSA-infected patients treated with vancomycin than among those treated with cloxacillin (47% vs. none; P
ISSN:1058-4838
1537-6591
DOI:10.1086/313440