Design and synthesis of a novel series of HIV-1 protease inhibitors

The synthesis and the SAR study of novel pseudo symmetric inhibitors of HIV-1 protease are described. Michael addition of amino acid derivatives to vinyl ketones was utilized to derive a potent (nM) series of HIV-1 protease inhibitors.

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry 1999-09, Vol.7 (9), p.2105-2114
Main Authors: TAKASHIRO, E, NAKAMURA, Y, MIYAMOTO, S, OZAWA, Y, SUGIYAMA, A, FUJIMOTO, K
Format: Article
Language:English
Subjects:
AIDS/HIV
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Biological and medical sciences
Drug Design
HIV Protease Inhibitors - chemical synthesis
HIV Protease Inhibitors - chemistry
HIV Protease Inhibitors - pharmacology
Medical sciences
Molecular Structure
Pharmacology. Drug treatments
Spectrum Analysis
Structure-Activity Relationship
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The synthesis and the SAR study of novel pseudo symmetric inhibitors of HIV-1 protease are described. Michael addition of amino acid derivatives to vinyl ketones was utilized to derive a potent (nM) series of HIV-1 protease inhibitors.
ISSN:0968-0896
1464-3391
DOI:10.1016/S0968-0896(99)00163-7