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Behavioral and Neuroendocrine Characteristics of the Night-Eating Syndrome
CONTEXT Investigators first described the night-eating syndrome (NES), which consists of morning anorexia, evening hyperphagia, and insomnia, in 1955, but, to our knowledge, this syndrome has never been subjected to careful clinical study. OBJECTIVE To characterize NES on the basis of behavioral cha...
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| Published in: | JAMA : the journal of the American Medical Association 1999-08, Vol.282 (7), p.657-663 |
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| container_issue | 7 |
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| container_title | JAMA : the journal of the American Medical Association |
| container_volume | 282 |
| creator | Birketvedt, Grethe Støa Florholmen, Jon Sundsfjord, Johan Østerud, Bjarne Dinges, David Bilker, Warren Stunkard, Albert |
| description | CONTEXT Investigators first described the night-eating syndrome (NES), which
consists of morning anorexia, evening hyperphagia, and insomnia, in 1955,
but, to our knowledge, this syndrome has never been subjected to careful clinical
study. OBJECTIVE To characterize NES on the basis of behavioral characteristics and neuroendocrine
data. DESIGN AND SETTING A behavioral observational study was conducted between January 1996
and June 1997 in a weight and eating disorders program at the University of
Pennsylvania. A neuroendocrine study was conducted from May through August
1997 at the Clinical Research Center of the University Hospital, Tromsö,
Norway. SUBJECTS The behavioral study included 10 obese subjects who met criteria for
NES and 10 matched control subjects. The neuroendocrine study included 12
night eaters and 21 control subjects. Behavioral study subjects were observed
for 1 week on an outpatient basis, and neuroendocrine study subjects were
observed during a 24-hour period in the hospital. MAIN OUTCOME MEASURES The behavioral study measured timing of energy intake, mood level, and
sleep disturbances. The neuroendocrine study measured circadian levels of
plasma melatonin, leptin, and cortisol. RESULTS In the behavioral study, compared with control subjects, night eaters
had more eating episodes in the 24 hours (mean [SD], 9.3 [0.6] vs 4.2 [0.2]; P |
| doi_str_mv | 10.1001/jama.282.7.657 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_70840714</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ama_id>191250</ama_id><sourcerecordid>70840714</sourcerecordid><originalsourceid>FETCH-LOGICAL-a463t-61a749788bf3b1d4f87c1b0a5b6ea286a0ec64140cfa963a4aeea9ab174d17e63</originalsourceid><addsrcrecordid>eNqF0c9L7DAQB_Agiu5Tr4IXKfJ4t66ZJk3Soy7qU0QP6rlM06mbpT80aQX_ewOuKF6cyxzmw8B8h7ED4HPgHE5W2OE8M9lcz1WuN9gMcmFSkRdmk804L0yqpZE77E8IKx4LhN5mO8Bz0BqKGbs-oyW-usFjm2BfJ7c0-YH6erDe9ZQslujRjuRdGJ0NydAk45KSW_e0HNNzHF3_lNy_9bUfOtpjWw22gfbXfZc9Xpw_LP6nN3eXV4vTmxSlEmOqALUstDFVIyqoZWO0hYpjXinCzCjkZJUEyW2DhRIokQgLrEDLGjQpscv-fex99sPLRGEsOxcstS32NEyh1NxIrkH-CkGrmBnXER7_gKth8n08oswgJiZElkV0tEZT1VFdPnvXoX8rP7OM4O8aYLDYNh5768KXKzLgYCI7_GDxc9-GkOVcvAMiWIoq</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>211373322</pqid></control><display><type>article</type><title>Behavioral and Neuroendocrine Characteristics of the Night-Eating Syndrome</title><source>AMA Current Titles</source><creator>Birketvedt, Grethe Støa ; Florholmen, Jon ; Sundsfjord, Johan ; Østerud, Bjarne ; Dinges, David ; Bilker, Warren ; Stunkard, Albert</creator><creatorcontrib>Birketvedt, Grethe Støa ; Florholmen, Jon ; Sundsfjord, Johan ; Østerud, Bjarne ; Dinges, David ; Bilker, Warren ; Stunkard, Albert</creatorcontrib><description>CONTEXT Investigators first described the night-eating syndrome (NES), which
consists of morning anorexia, evening hyperphagia, and insomnia, in 1955,
but, to our knowledge, this syndrome has never been subjected to careful clinical
study. OBJECTIVE To characterize NES on the basis of behavioral characteristics and neuroendocrine
data. DESIGN AND SETTING A behavioral observational study was conducted between January 1996
and June 1997 in a weight and eating disorders program at the University of
Pennsylvania. A neuroendocrine study was conducted from May through August
1997 at the Clinical Research Center of the University Hospital, Tromsö,
Norway. SUBJECTS The behavioral study included 10 obese subjects who met criteria for
NES and 10 matched control subjects. The neuroendocrine study included 12
night eaters and 21 control subjects. Behavioral study subjects were observed
for 1 week on an outpatient basis, and neuroendocrine study subjects were
observed during a 24-hour period in the hospital. MAIN OUTCOME MEASURES The behavioral study measured timing of energy intake, mood level, and
sleep disturbances. The neuroendocrine study measured circadian levels of
plasma melatonin, leptin, and cortisol. RESULTS In the behavioral study, compared with control subjects, night eaters
had more eating episodes in the 24 hours (mean [SD], 9.3 [0.6] vs 4.2 [0.2]; P<.001) and consumed significantly more of their daily
energy intake at night than did control subjects (56% vs 15%; P<.001). They averaged 3.6 (0.9) awakenings per night compared with
0.3 (0.3) by controls (P<.001). In night eaters,
52% of these awakenings were associated with food intake, with a mean intake
per ingestion of 1134 (1197) kJ. None of the controls ate during their awakenings.
In the neuroendocrine study, compared with control subjects, night eaters
had attenuation of the nocturnal rise in plasma melatonin and leptin levels
(P<.001 for both) and higher circadian levels
of plasma cortisol (P = .001). CONCLUSION A coherent pattern of behavioral and neuroendocrine characteristics
was found in subjects with NES.</description><identifier>ISSN: 0098-7484</identifier><identifier>EISSN: 1538-3598</identifier><identifier>DOI: 10.1001/jama.282.7.657</identifier><identifier>PMID: 10517719</identifier><identifier>CODEN: JAMAAP</identifier><language>eng</language><publisher>Chicago, IL: American Medical Association</publisher><subject>Adult ; Anorexia - physiopathology ; Biological and medical sciences ; Circadian Rhythm - physiology ; Feeding and Eating Disorders - physiopathology ; Feeding Behavior - physiology ; Female ; Humans ; Hydrocortisone - blood ; Hyperphagia - physiopathology ; Leptin ; Male ; Medical sciences ; Melatonin - blood ; Metabolic diseases ; Neurosecretory Systems - physiology ; Obesity ; Poisson Distribution ; Proteins - metabolism ; Regression Analysis ; Sleep Initiation and Maintenance Disorders - physiopathology ; Statistics, Nonparametric ; Syndrome</subject><ispartof>JAMA : the journal of the American Medical Association, 1999-08, Vol.282 (7), p.657-663</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright American Medical Association Aug 18, 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a463t-61a749788bf3b1d4f87c1b0a5b6ea286a0ec64140cfa963a4aeea9ab174d17e63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1921018$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10517719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Birketvedt, Grethe Støa</creatorcontrib><creatorcontrib>Florholmen, Jon</creatorcontrib><creatorcontrib>Sundsfjord, Johan</creatorcontrib><creatorcontrib>Østerud, Bjarne</creatorcontrib><creatorcontrib>Dinges, David</creatorcontrib><creatorcontrib>Bilker, Warren</creatorcontrib><creatorcontrib>Stunkard, Albert</creatorcontrib><title>Behavioral and Neuroendocrine Characteristics of the Night-Eating Syndrome</title><title>JAMA : the journal of the American Medical Association</title><addtitle>JAMA</addtitle><description>CONTEXT Investigators first described the night-eating syndrome (NES), which
consists of morning anorexia, evening hyperphagia, and insomnia, in 1955,
but, to our knowledge, this syndrome has never been subjected to careful clinical
study. OBJECTIVE To characterize NES on the basis of behavioral characteristics and neuroendocrine
data. DESIGN AND SETTING A behavioral observational study was conducted between January 1996
and June 1997 in a weight and eating disorders program at the University of
Pennsylvania. A neuroendocrine study was conducted from May through August
1997 at the Clinical Research Center of the University Hospital, Tromsö,
Norway. SUBJECTS The behavioral study included 10 obese subjects who met criteria for
NES and 10 matched control subjects. The neuroendocrine study included 12
night eaters and 21 control subjects. Behavioral study subjects were observed
for 1 week on an outpatient basis, and neuroendocrine study subjects were
observed during a 24-hour period in the hospital. MAIN OUTCOME MEASURES The behavioral study measured timing of energy intake, mood level, and
sleep disturbances. The neuroendocrine study measured circadian levels of
plasma melatonin, leptin, and cortisol. RESULTS In the behavioral study, compared with control subjects, night eaters
had more eating episodes in the 24 hours (mean [SD], 9.3 [0.6] vs 4.2 [0.2]; P<.001) and consumed significantly more of their daily
energy intake at night than did control subjects (56% vs 15%; P<.001). They averaged 3.6 (0.9) awakenings per night compared with
0.3 (0.3) by controls (P<.001). In night eaters,
52% of these awakenings were associated with food intake, with a mean intake
per ingestion of 1134 (1197) kJ. None of the controls ate during their awakenings.
In the neuroendocrine study, compared with control subjects, night eaters
had attenuation of the nocturnal rise in plasma melatonin and leptin levels
(P<.001 for both) and higher circadian levels
of plasma cortisol (P = .001). CONCLUSION A coherent pattern of behavioral and neuroendocrine characteristics
was found in subjects with NES.</description><subject>Adult</subject><subject>Anorexia - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Circadian Rhythm - physiology</subject><subject>Feeding and Eating Disorders - physiopathology</subject><subject>Feeding Behavior - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Hydrocortisone - blood</subject><subject>Hyperphagia - physiopathology</subject><subject>Leptin</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Melatonin - blood</subject><subject>Metabolic diseases</subject><subject>Neurosecretory Systems - physiology</subject><subject>Obesity</subject><subject>Poisson Distribution</subject><subject>Proteins - metabolism</subject><subject>Regression Analysis</subject><subject>Sleep Initiation and Maintenance Disorders - physiopathology</subject><subject>Statistics, Nonparametric</subject><subject>Syndrome</subject><issn>0098-7484</issn><issn>1538-3598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqF0c9L7DAQB_Agiu5Tr4IXKfJ4t66ZJk3Soy7qU0QP6rlM06mbpT80aQX_ewOuKF6cyxzmw8B8h7ED4HPgHE5W2OE8M9lcz1WuN9gMcmFSkRdmk804L0yqpZE77E8IKx4LhN5mO8Bz0BqKGbs-oyW-usFjm2BfJ7c0-YH6erDe9ZQslujRjuRdGJ0NydAk45KSW_e0HNNzHF3_lNy_9bUfOtpjWw22gfbXfZc9Xpw_LP6nN3eXV4vTmxSlEmOqALUstDFVIyqoZWO0hYpjXinCzCjkZJUEyW2DhRIokQgLrEDLGjQpscv-fex99sPLRGEsOxcstS32NEyh1NxIrkH-CkGrmBnXER7_gKth8n08oswgJiZElkV0tEZT1VFdPnvXoX8rP7OM4O8aYLDYNh5768KXKzLgYCI7_GDxc9-GkOVcvAMiWIoq</recordid><startdate>19990818</startdate><enddate>19990818</enddate><creator>Birketvedt, Grethe Støa</creator><creator>Florholmen, Jon</creator><creator>Sundsfjord, Johan</creator><creator>Østerud, Bjarne</creator><creator>Dinges, David</creator><creator>Bilker, Warren</creator><creator>Stunkard, Albert</creator><general>American Medical Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19990818</creationdate><title>Behavioral and Neuroendocrine Characteristics of the Night-Eating Syndrome</title><author>Birketvedt, Grethe Støa ; Florholmen, Jon ; Sundsfjord, Johan ; Østerud, Bjarne ; Dinges, David ; Bilker, Warren ; Stunkard, Albert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a463t-61a749788bf3b1d4f87c1b0a5b6ea286a0ec64140cfa963a4aeea9ab174d17e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Anorexia - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Circadian Rhythm - physiology</topic><topic>Feeding and Eating Disorders - physiopathology</topic><topic>Feeding Behavior - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Hydrocortisone - blood</topic><topic>Hyperphagia - physiopathology</topic><topic>Leptin</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Melatonin - blood</topic><topic>Metabolic diseases</topic><topic>Neurosecretory Systems - physiology</topic><topic>Obesity</topic><topic>Poisson Distribution</topic><topic>Proteins - metabolism</topic><topic>Regression Analysis</topic><topic>Sleep Initiation and Maintenance Disorders - physiopathology</topic><topic>Statistics, Nonparametric</topic><topic>Syndrome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Birketvedt, Grethe Støa</creatorcontrib><creatorcontrib>Florholmen, Jon</creatorcontrib><creatorcontrib>Sundsfjord, Johan</creatorcontrib><creatorcontrib>Østerud, Bjarne</creatorcontrib><creatorcontrib>Dinges, David</creatorcontrib><creatorcontrib>Bilker, Warren</creatorcontrib><creatorcontrib>Stunkard, Albert</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>JAMA : the journal of the American Medical Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Birketvedt, Grethe Støa</au><au>Florholmen, Jon</au><au>Sundsfjord, Johan</au><au>Østerud, Bjarne</au><au>Dinges, David</au><au>Bilker, Warren</au><au>Stunkard, Albert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Behavioral and Neuroendocrine Characteristics of the Night-Eating Syndrome</atitle><jtitle>JAMA : the journal of the American Medical Association</jtitle><addtitle>JAMA</addtitle><date>1999-08-18</date><risdate>1999</risdate><volume>282</volume><issue>7</issue><spage>657</spage><epage>663</epage><pages>657-663</pages><issn>0098-7484</issn><eissn>1538-3598</eissn><coden>JAMAAP</coden><abstract>CONTEXT Investigators first described the night-eating syndrome (NES), which
consists of morning anorexia, evening hyperphagia, and insomnia, in 1955,
but, to our knowledge, this syndrome has never been subjected to careful clinical
study. OBJECTIVE To characterize NES on the basis of behavioral characteristics and neuroendocrine
data. DESIGN AND SETTING A behavioral observational study was conducted between January 1996
and June 1997 in a weight and eating disorders program at the University of
Pennsylvania. A neuroendocrine study was conducted from May through August
1997 at the Clinical Research Center of the University Hospital, Tromsö,
Norway. SUBJECTS The behavioral study included 10 obese subjects who met criteria for
NES and 10 matched control subjects. The neuroendocrine study included 12
night eaters and 21 control subjects. Behavioral study subjects were observed
for 1 week on an outpatient basis, and neuroendocrine study subjects were
observed during a 24-hour period in the hospital. MAIN OUTCOME MEASURES The behavioral study measured timing of energy intake, mood level, and
sleep disturbances. The neuroendocrine study measured circadian levels of
plasma melatonin, leptin, and cortisol. RESULTS In the behavioral study, compared with control subjects, night eaters
had more eating episodes in the 24 hours (mean [SD], 9.3 [0.6] vs 4.2 [0.2]; P<.001) and consumed significantly more of their daily
energy intake at night than did control subjects (56% vs 15%; P<.001). They averaged 3.6 (0.9) awakenings per night compared with
0.3 (0.3) by controls (P<.001). In night eaters,
52% of these awakenings were associated with food intake, with a mean intake
per ingestion of 1134 (1197) kJ. None of the controls ate during their awakenings.
In the neuroendocrine study, compared with control subjects, night eaters
had attenuation of the nocturnal rise in plasma melatonin and leptin levels
(P<.001 for both) and higher circadian levels
of plasma cortisol (P = .001). CONCLUSION A coherent pattern of behavioral and neuroendocrine characteristics
was found in subjects with NES.</abstract><cop>Chicago, IL</cop><pub>American Medical Association</pub><pmid>10517719</pmid><doi>10.1001/jama.282.7.657</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0098-7484 |
| ispartof | JAMA : the journal of the American Medical Association, 1999-08, Vol.282 (7), p.657-663 |
| issn | 0098-7484 1538-3598 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70840714 |
| source | AMA Current Titles |
| subjects | Adult Anorexia - physiopathology Biological and medical sciences Circadian Rhythm - physiology Feeding and Eating Disorders - physiopathology Feeding Behavior - physiology Female Humans Hydrocortisone - blood Hyperphagia - physiopathology Leptin Male Medical sciences Melatonin - blood Metabolic diseases Neurosecretory Systems - physiology Obesity Poisson Distribution Proteins - metabolism Regression Analysis Sleep Initiation and Maintenance Disorders - physiopathology Statistics, Nonparametric Syndrome |
| title | Behavioral and Neuroendocrine Characteristics of the Night-Eating Syndrome |
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