Enantioselective Synthesis of β-Hydroxy Acid Derivatives via a One-Pot Aldol Reaction−Dynamic Kinetic Resolution

Combining dynamic kinetic resolution with an aldol reaction provides access to β-hydroxy ester derivatives with high enantiomeric purity (up to 99% ee) in a one-pot procedure. Only simple starting materials are required in this enantioselective process, and preformation of a silyl enol ether is not...

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Bibliographic Details
Published in:Organic letters 2001-04, Vol.3 (8), p.1209-1212
Main Authors: Huerta, Fernando F, Bäckvall, Jan-E
Format: Article
Language:English
Subjects:
Aldehydes - chemistry
Carbon - chemistry
Chemistry, Organic - methods
Esters - chemistry
Ethers - chemistry
Kinetics
Models, Chemical
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Summary:Combining dynamic kinetic resolution with an aldol reaction provides access to β-hydroxy ester derivatives with high enantiomeric purity (up to 99% ee) in a one-pot procedure. Only simple starting materials are required in this enantioselective process, and preformation of a silyl enol ether is not necessary.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol015682p