New Perspectives on Iron: An Introduction

Iron is an essential nutritional element for all life forms. Iron plays critical roles in electron transport and cellular respiration, cell proliferation and differentiation, and regulation of gene expression. Two emerging new functions for iron are its necessary role in supporting transcription of...

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Bibliographic Details
Published in:The American journal of the medical sciences 1999-10, Vol.318 (4), p.207-212
Main Author: Boldt, David H.
Format: Article
Language:English
Subjects:
Acid Phosphatase - metabolism
Animals
Cell Division
Cell Respiration
Electron Transport
Gene Expression Regulation
Gene transcription
Hematopoiesis
Hematopoietic differentiation
Hemochromatosis - metabolism
Humans
Iron
Iron - metabolism
Iron - physiology
Macrophages - physiology
Monocytes - physiology
Oxidation-Reduction
p21 (WAF1/CIP1)
Protein kinase C
Protein Kinase C - metabolism
Reactive oxygen species
Reactive Oxygen Species - metabolism
Receptors, Transferrin - metabolism
Tartrate resistant acid phosphatase
Transcription, Genetic
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Summary:Iron is an essential nutritional element for all life forms. Iron plays critical roles in electron transport and cellular respiration, cell proliferation and differentiation, and regulation of gene expression. Two emerging new functions for iron are its necessary role in supporting transcription of certain key genes required for cell growth and function [eg, nitric oxide synthase, protein kinase C-β, p21 (CIP1/WAF1)] and its complex role in hematopoietic cell differentiation. However, iron is also potentially deleterious. Reactive oxygen species generated by Fenton chemistry may contribute to major pathological processes such as cancer, atherosclerosis, and neurodegenerative diseases. Iron-generated reactive oxygen species may also function in normal intracellular signaling. Therefore, roles of iron are both essential and extraordinarily diverse. This symposium explores this diversity by covering topics of iron absorption and transport, the regulation of gene expression by iron responsive proteins, the cellular biology of heme, hereditary hemochromatosis, and clinical use of serum transferrin receptor measurements.
ISSN:0002-9629
1538-2990
DOI:10.1016/S0002-9629(15)40625-1