A novel method to highly versatile monomeric PNA building blocks by multi component reactions

A novel approach to monomeric PNA building blocks by a solution phase Ugi multi component reaction (MCR) is described. The reaction is easily performed in 96 well plates. The products precipitate from the reaction solution and are thus obtained in high yields and purity. Those products are not amena...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1999-10, Vol.9 (19), p.2871-2874
Main Authors: Dömling, Alexander, Chi, Kai-Zu, Barrère, Mathieux
Format: Article
Language:English
Subjects:
Amines - chemistry
Carbohydrates. Nucleosides and nucleotides
Chemistry
Combinatorial Chemistry Techniques
Exact sciences and technology
Magnetic Resonance Spectroscopy
Molecular Structure
Nucleosides, nucleotides and oligonucleotides
Organic chemistry
Peptide Nucleic Acids - chemical synthesis
Preparations and properties
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Summary:A novel approach to monomeric PNA building blocks by a solution phase Ugi multi component reaction (MCR) is described. The reaction is easily performed in 96 well plates. The products precipitate from the reaction solution and are thus obtained in high yields and purity. Those products are not amenable by another multi step synthesis in such a diversity. Graphic
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(99)00491-6