Transmembrane Ion Conductance by an Acyclic Bolaamphiphile

An acyclic bolaamphiphile forms ion channels in vesicles and planar bilayer membranes that are closely similar to the channels formed by related bismacrocyclic compounds. Thus the function of these ion channels does not depend on synthetically difficult macrocyclic subunits.

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Bibliographic Details
Published in:Organic letters 2001-05, Vol.3 (9), p.1335-1337
Main Authors: Fyles, Thomas M, Hu, Chi-wei, Knoy, Ryan
Format: Article
Language:English
Subjects:
Biological Transport
Ion Channels - chemistry
Ion Channels - metabolism
Lipid Bilayers - chemistry
Magnetic Resonance Spectroscopy
Membranes - chemistry
Membranes - metabolism
Models, Molecular
Molecular Structure
Phosphatidylcholines - chemistry
Structure-Activity Relationship
Surface-Active Agents - chemistry
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Description
Summary:An acyclic bolaamphiphile forms ion channels in vesicles and planar bilayer membranes that are closely similar to the channels formed by related bismacrocyclic compounds. Thus the function of these ion channels does not depend on synthetically difficult macrocyclic subunits.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol015713g